| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Carcinoma cells exhibit a high level of robustness against environmental stresses, metabolic disorders and therapeutic efforts. Here, we provide a novel mechanism of the squamous cell carcinoma development by THG-1, a Tsc-22 family protein. THG-1 localized in the basal layer of normal squamous epithelium and overexpressed in squamous cell carcinomas. THG-1 knockdown suppresses the cell proliferation, invasiveness and tumorigenicity. THG-1 is phosphorylated by the receptor tyrosine kinase-Ras-ERK pathway, which is required for
oncogenic Ras-mediated tumorigenesis. Furthermore, THG-1 interacts with several factors that regulate the cell proliferation, cytoprotection, metabolism and microenvironment. Our results highlight the pivotal role of THG-1 as a novel regulator of tumorigenssis under the oncogenic signaling pathway.
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