Roles of Tsc-22 family proteins in cell proliferation, differentiation and tumorigenesis
| Project/Area Number |
25460472
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | THG-1 / 扁平上皮がん / EGF / Ras / Tsc-22 family / がん / 扁平上皮 / 細胞増殖 / 転移 |
|---|
| Outline of Final Research Achievements |
Carcinoma cells exhibit a high level of robustness against environmental stresses, metabolic disorders and therapeutic efforts. Here, we provide a novel mechanism of the squamous cell carcinoma development by THG-1, a Tsc-22 family protein. THG-1 localized in the basal layer of normal squamous epithelium and overexpressed in squamous cell carcinomas. THG-1 knockdown suppresses the cell proliferation, invasiveness and tumorigenicity. THG-1 is phosphorylated by the receptor tyrosine kinase-Ras-ERK pathway, which is required for
oncogenic Ras-mediated tumorigenesis. Furthermore, THG-1 interacts with several factors that regulate the cell proliferation, cytoprotection, metabolism and microenvironment. Our results highlight the pivotal role of THG-1 as a novel regulator of tumorigenssis under the oncogenic signaling pathway.
|
Report
(4 results)
Research Products
(19 results)
-
[Journal Article] β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.2016
Author(s)
Ahmed M. Abdellatif, Hisashi Oishi , Takahiro Itagaki, Yunshin Jung, Hossam H. Shawki, Yukari Okita, Yoshikazu Hasegawa, Hiroyuki Suzuki, Salah E. El-Morsy, Mesbah A. El-Sayed, Mahmoud B. Shoaib, Fumihiro Sugiyama, Satoru Takahashi
-
Journal Title
PLoS One.
Volume: 11
Issue: 2
Pages: e0150010-e0150010
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
