| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The lymphatic system is a network of lymphatic vessels throughout the body which collect excess lymph fluid. Impaired flow of the lymphatic system results in lymphedema. The present study attempted to establish induced lymphatic endothelial cells using direct reprogramming. Introduction of several transcription factors to fibroblasts including Prox1 led to the increased expression of various lymphatic endothelial cells. Furthermore, addition of specific inhibitors for TGF-β increased the proliferation of lymphatic endothelial cells, and the expression of lymphatic endothelial cell markers. These findings will aid to establish novel therapeutic methods for the regenerative medicine of lymphedema.
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