| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In invasive fronts of esophageal squamous cell carcinoma (ESCC), there are some tumor cells displaying EMT-like morphology, and they show not only ZEB1, an EMT marker, but also nuclear expression of Notch1 (ICN1). We demonstrated that a specific expression pattern of ICN1 correlates significantly with poorer prognosis of ESCC patients, and also associated with tumor depth, lymphatic and venous invasion, and lymph node and distant metastasis. The positive rate of this ICN1 expression is significantly higher in ESCC samples from patients who have undergone chemoradiation therapy and local recurrence lesions, suggesting that it could be an important marker of bad prognosis, recurrence, and metastasis of ESCC.
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