A study for local invasion promoting factor of esophageal squamous cell carcinoma
Project/Area Number |
25460474
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
|
Research Institution | Kochi University |
Principal Investigator |
Naganuma Seiji 高知大学, 教育研究部医療学系基礎医学部門, 助教 (50452123)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 食道扁平上皮癌 / 浸潤転移 / Notchシグナリング / EMT / 食道癌 / Notch1 / 癌浸潤 / 予後因子 / Notch / レーザーマイクロダイセクション |
Outline of Final Research Achievements |
In invasive fronts of esophageal squamous cell carcinoma (ESCC), there are some tumor cells displaying EMT-like morphology, and they show not only ZEB1, an EMT marker, but also nuclear expression of Notch1 (ICN1). We demonstrated that a specific expression pattern of ICN1 correlates significantly with poorer prognosis of ESCC patients, and also associated with tumor depth, lymphatic and venous invasion, and lymph node and distant metastasis. The positive rate of this ICN1 expression is significantly higher in ESCC samples from patients who have undergone chemoradiation therapy and local recurrence lesions, suggesting that it could be an important marker of bad prognosis, recurrence, and metastasis of ESCC.
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Report
(4 results)
Research Products
(4 results)
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[Presentation] Nuclear Notch1 expression is associated with treatment failure and predicts prognosis in patients with esophageal squamous cell carcinoma2016
Author(s)
Yoshiaki Kita, Seiji Naganuma, Hiroshi Nakagawa, Hiroshi Okumura, Yasuto Uchikado, Takaaki Arigami, Ken Sasaki, Kiyonori Tanoue, Itaru Omoto, Kenji Baba, Shinichiro Mori, Yoshikazu Uenososno, Yuko Mataki, Yuko Kijima, Kosei Maemura, Shoji Natsugoe
Organizer
SSO (Society of Surgical Oncology) 2016 Annual Cancer Symposium
Place of Presentation
Boston, MA
Year and Date
2016-03-02
Related Report
Int'l Joint Research
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[Presentation] Autophagy Regulates Esophageal Cancer Stem Cell Phenotypic Plasticity by Targeting Mitochondria and Oxidative Stress2014
Author(s)
Kelly A. Whelan, Shingo Kagawa, Andy Guo, Mitsuteru Natsuizaka, Hideaki Kinugasa, Shinya Ohashi, Yoshiaki Kita, Shoji Natsugoe, Seiji Naganuma, Andres J. Klein-Szanto, Ravi K. Amaravadi, Anil K. Rustgi, Hiroshi Nakagawa
Organizer
Digestive Disease Week 2014
Place of Presentation
Chicago, IL (USA)
Year and Date
2014-05-04 – 2014-05-06
Related Report
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