| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The followings were revealed in this study: (1) Abnormality of a part of DNA repair gene is associated with centrosome amplification. (2) SASS6 overexpression is associated with centrosome amplification, mitotic chromosomal abnormalities, chromosome instability, and a poor prognosis in patients with colorectal cancer. (3) Overexpression of a SGOL1 splicing variant type B (SGOL1-B) is associated with centrosome amplification, abnormal mitosis, and resistance to taxane in non-small cell lung cancer. (4) Amplification of STK15（AURAK）gene which is involved in the centrosome regulation is a predictor of a poor prognosis in patients with gastric cancer. (5) Abnormal expressions of DNA glycosylase genes NEIL1, NEIL2, and NEIL3 are associated with somatic mutation loads in human cancer.
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