| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The TLS-CHOP gene specifically seen in myxoid liposarcoma is a chimeric oncogene that is derived from chromosomal translocation. The gene product functions as a transcription factor, and is thought to be involved in tumorigenesis and tumor cell growth. Its detailed molecular mechanism is, however, still unclear. Previous studies have shown that TLS-CHOP induces expression of a transforming-related protein DOL54 and represses expression of an anti-tumor cytokine IL-24. In this study, we have revealed that overrexpression of DOL54 represses IL-24 expression, contributing to maintenance of tumor cell growth. Furthermore, we have identified several molecules related to growth of myxoid liposarcoma cells, and are investigating their molecular functions now at present.
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