Molecular mechanisms to form antitumor immune microenvironment

Research Project

Project/Area Number	25460486
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Experimental pathology
Research Institution	National Cancer Center Japan
Principal Investigator	Hiraoka Nobuyoshi 国立研究開発法人国立がん研究センター, 中央病院, 科長 (40276217)
Co-Investigator(Kenkyū-buntansha)	ISHIKAWA Yoshinori (INO Yoshinori) 国立がん研究センター研究所, バイオマーカー評価部門, 主任研究官 (90291137)
Co-Investigator(Renkei-kenkyūsha)	YAMAZAKI Rie 国立がん研究センター研究所, 分子病理分野, 特任研究員
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	EBI3 / 膵がん
Outline of Final Research Achievements	Tumor microenvironment can determine the biological behavior of the cancer. The aim of the study was to investigate roles of EBI3 in the formation of anti-tumor immune microenvironment. We examined roles of EBI3 using our newly designed transgenic mice expressing dominant-negative inactive form EBI3 and analyzing tumor formation in those mice treated with chemical carcinogens. Carcinogen-induced tumors developed earlier and more frequently in the transgenic mice rather than wild type mice, suggesting that EBI3 involves in the antitumor immune microenvironment. Clinicopathological examinations also suggested that higher infiltration of EBI3 expressing cells into tumor tissues is a favorable prognosticator in various types of solid cancer other than pancreatic cancer.