| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Deletion of PPARα in liver-specific HNF4α-null mice (KO mice) improved NASH. Expression of FATP1, CD36, and CideA was increased in KO mice, but the expression of these genes were decreased in double KO mice. Also, DNA binding activity of PPARα and the amount of hepatic fatty acid was increased in KO mice. These results indicate that ligand-activated PPARα/PGC1α could transactivate the PPARα target genes and might induce NASH in KO mice.
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