Development of therapeutic strategy by using recombinant-inbred model mouse strains of collagen disease
Project/Area Number |
25460496
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Gifu University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
MASUMOTO Junya 愛媛大学, プロテオ医学研究センター, 教授 (20334914)
NOSE Masato 愛媛大学, 医学系研究科, 名誉教授 (70030913)
HASEGAWA Hitoshi 愛媛大学, 医学系研究科, 特任教授 (40164826)
FUJINO Takahiro 愛媛大学, 学術支援センター, 准教授 (40292312)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 炎症 / 膠原病脂環モデルマウス / 組換え近交系 / 蛋白アナログ / 病理学 / 膠原病モデルマウス / 膠原病疾患モデルマウス |
Outline of Final Research Achievements |
We have developed the polygene model murine strains of collagen diseases MXH/lpr. By using these strains, we aimed to evolve a new therapeutic strategy employing amino-acid analogue which might block the functional binding site of Opn AND/OR might work as a decoy of autoantigens. First, we established 23 strains of MXH/lpr recombinant inbred mice (among created 106 strains). Next, we screened the epitope of autoantigen of glomerulonephritis. Modulation of immune function by protein analogue administration was analyzed. Regarding the new drug delivery system, preliminary study of a novel DDS by Span 80 nano-vesicles were executed. Finally, the administration of amino-acid analogues to the collagen model mice strains were carried out.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes.2015
Author(s)
Mokuda S, Miyazaki T, Ito Y, Yamasaki S, Inoue H, Guo Y, Kong WS, Kanno M, Takasugi K, Sugiyama E, Masumoto J.
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 9795-9795
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Novel Autoantigens Associated with Lupus Nephritis.2015
Author(s)
Onishi S, Adnan E, Ishizaki J, Miyazaki T, Tanaka Y, Matsumoto T, Suemori K, Shudou M, Okura T, Takeda H, Sawasaki T, Yasukawa M, Hasegawa H.
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Journal Title
PLoS One.
Volume: 10
Issue: 6
Pages: e0126564-e0126564
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Expression of prorenin receptor in renal biopsies from patients with IgA nephropathy.2014
Author(s)
Miyazaki N, Murata I, Takemura G, Okada H, Kanamori H, Matsumoto-Miyazaki J, Yoshida G, Izumi K, Kashi H, Niimi K, Nishiwaki A, Miyazaki T, Ohno M, Ohashi H, Suzuki F, Minatoguchi S.
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Journal Title
International journal of clinical and experimental pathology.
Volume: 7
Pages: 7485-7496
Related Report
Peer Reviewed / Open Access
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[Journal Article] A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus mice2013
Author(s)
Oishi, H., Tsubaki, T., Miyazaki, T., Ono, M., Nose, M. and Tahahashi, S.
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Journal Title
Journal of Immunology
Volume: 190
Issue: 5
Pages: 2129-2137
DOI
Related Report
Peer Reviewed
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[Presentation] 自己抗体ループス腎炎の新たな自己抗原の同定と解析2015
Author(s)
大西佐知子, 石崎淳, 宮崎龍彦, 山崎仁志, 末盛浩一郎, 松本卓也, 安川正貴, 長谷川均
Organizer
日本リウマチ学会総会・学術集集会・国際リウマチシンポジウム
Place of Presentation
名古屋市
Year and Date
2015-04-23
Related Report
Int'l Joint Research
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