The significance of macrophage activation in tumor development and inflammation
| Project/Area Number |
25460497
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | マクロファージ / CD163 / 炎症 / 腫瘍 |
|---|
| Outline of Final Research Achievements |
CD163 is detected specifically on macrophages, and is known to be up-regulated in cancers, sepsis, and metabolic syndrome. Th2-type cytokine preferentially induce CD163 on macrophages, and therefore considered to be a marker for M2 phenotype. In human cancer, high density of CD163-positive macrophages in tumor microenvironment was well correlated to worse clinical prognosis, and these findings indicate the significant involvement of CD163 in protumor activation of macrophages. In addition to cancers, CD163 was up-regulated in septic shock and metabolic syndrome. However, the detail mechanisms of CD163-related macrophage activation have still never been uncovered. In the present study, we tried to investigate the significance of CD163-related signals in murine disease models.
|
Report
(4 results)
Research Products
(23 results)
-
-
[Journal Article] Podocyte p53 limits the severity of experimental Alport syndrome.2016
Author(s)
Fukuda R, Suico MA, Kai Y, Omachi K, Motomura K, Koga T, Komohara Y, Koyama K, Yokota T, Taura M, Shuto T, Kai H
-
Journal Title
J Am Soc Nephrol
Volume: 27
Pages: 144-157
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Prognostic significance of CD169+ lymph node sinus macrophages in patients with malignant melanoma.2015
Author(s)
Saito Y, Ohnishi K, Miyashita A, Nakahara S, Fujiwara Y, Horlad H, Motoshima T, Fukushima S, Jinnin M, Ihn H, Takeya M, Komohara Y.
-
Journal Title
Cancer Immunol Res
Volume: 3
Pages: 1356-1363
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas.2015
Author(s)
Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M.
-
Journal Title
Cancer Immunol Res
Volume: 3
Pages: 999-1007
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease2014
Author(s)
Kaku Y, Imaoka H, Morimatsu Y, Komohara Y, Ohnishi K, Oda H, Takenaka S, Matsuoka M, Kawayama T, Takeya M, Hoshino T
-
Journal Title
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation.2014
Author(s)
Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, Okabe H, Hidaka K, Yokoyama N, Miyake K, Yoshikawa M, Nagano O, Komohara Y, Takeya M, Saya H, Baba H.
-
Journal Title
Carcinogenesis
Volume: 35
Pages: 1003-1011
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
