Establishment of mouse model for tumor antibody therapy using bio-imaging system
Project/Area Number |
25460499
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Kumamoto University |
Principal Investigator |
Okada Seiji 熊本大学, エイズ学研究センター, 教授 (50282455)
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Research Collaborator |
KARIYA Ryusho
GOTO Hiroki
Vaeteewoottacharn Kulthida
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 抗体療法 / マウスモデル / 高度免疫不全マウス / 原発性滲出性リンパ腫 / 胆管細胞がん / CD47 / IL-6R / 生体イメージング / 悪性リンパ腫 / NK細胞 / マクロファージ |
Outline of Final Research Achievements |
The aim of this study is to establish evaluation system of antibody therapy for human malignancies using in vivo imaging system. We established the evaluation system of anti-tumor therapy using human tumor transplantation model into novel hairless highly immunodeficient mice. In primary effusion lymphoma (PEL) and cholangiocarcinoma (CCA) model, we showed that anti-CD47 Antibody (Ab), anti-IL6R Ab and Anti-VEGF Ab effectively suppressed the tumor growth. We also confirmed that human NK cells could form and grow in highly immunodeficient mice. We are now planning to establish the evaluation system of Antibody-dependent cell cytotoxicity (ADCC) using Abs and NK cells. Thus, we successfully established the effective evaluation system for treatment of human malignancies using novel hairless immunodeficient mice and in vivo imaging system.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma2016
Author(s)
Vaeteewoottacharn K, Kariya R, Dana P, Fujikawa S, Matsuda K, Ohkuma K, Kudo E, Kraiklang R, Wongkham C, Wongkham S, Okada S.
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Journal Title
Tumour Biol
Volume: 0
Pages: 0-0
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Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Book] リンパ腫学2015
Author(s)
四本美保子、岡田誠治
Total Pages
695
Publisher
日本臨床社
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