Validation of the "strain" difference of Angiostrongylus cantonensis in susceptible and non-susceptible hosts related to the disease pathogenesis
Project/Area Number |
25460513
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Parasitology (including sanitary zoology)
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
AKAO Nobuaki 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (00126559)
|
Co-Investigator(Kenkyū-buntansha) |
関 丈典 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (60631728)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 広東住血線虫 / 遺伝的多形性 / 病原性 / スナネズミ / 感染感受性 / 遺伝的多様性 / 好酸球 / 分離株 / IL-33 / 脳脊髄液 / biomarker |
Outline of Final Research Achievements |
We investigated the disease susceptibility of Mongolian gerbil for Angiostrongylus cantonensis (Ac) infection among the isolates exhibiting phylogenetic diversity. The results obtained as follows: 1) all the gerbils infected with 10 larvae of the Hawaiian strain of Ac were dying until 45 days after infection. On the other hand, prolongation of the provability of survivals in gerbils infected with the Ogasawara strain and the Chiba strain were observed. 2) On the 45th day of infection, adult parasites were recovered from pulmonary arteries and heart in the Hawaiian and the Ogasawara strains of Ac, and they showed actively motile. The 1st stage larvae were found in their stools. However, most of parasites found in gerbils infected with the Chiba strain were persisted in the brain and died there. These results indicated that different genetic diversity among Ac strains shows different pathogenesis in gerbils.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Molecular identification of Anisakis and Hysterothylacium larvae in marine fishes from the East China Sea and the Pacific coast of central Japan2015
Author(s)
Kong, Q. Fan, L. Zhang, J. Akao, N. Dong, K. Lou, D. Ding, J. Tong, Q. Zheng, B. Chen, R. Ohta, N. Lu, S.
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Journal Title
Int J Food Microbiol
Volume: 199
Pages: 1-7
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Loiasis in a Japanese Traveler Returning from Central Africa2015
Author(s)
Kobayashi T, Hayakawa K, Mawatari M, Itoh M, Akao N, Yotsu RR, Sugihara J, Takeshita N, Kutsuna S, Fujiya Y, Kanagawa S, Ohmagari N, Kato Y.
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Journal Title
Tropical Medicine and Health
Volume: 43
Issue: 2
Pages: 149-153
DOI
NAID
ISSN
1348-8945, 1349-4147
Related Report
Peer Reviewed
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[Journal Article] Molecular genotyping of anisakis larvae in Middle Eastern Japan and endoscopic evidence for preferential penetration of normal over atrophic mucosa.2014
Author(s)
Arai T, Akao N, Seki T, Kumagai T, Ishikawa H, Ohta N, Hirata N, Nakaji S, Yamauchi K, Hirai M, Shiratori T, Kobayashi M, Fujii H, Ishii E, Naito M, Saitoh S, Yamaguchi T, Shibata N, Shimo M, Tokiwa T.
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Journal Title
PLoS One.
Volume: 9(2)
Issue: 2
Pages: e89188-e89188
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Basophil depletion downregulates Schistosoma mansoni egg-induced granuloma formation2013
Author(s)
Anyan, W.K., Seki, T., Kumagai, T., Obata-Ninomiya, K., Furushima-Shimogawara, R., Kwansa-Bentum, B., Akao, N., Bosompem, K.M., Boakye, D.A., Wilson, M.D., Karasuyama, H., and Ohta, N.
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Journal Title
Parasitol. Int.
Volume: 62
Issue: 6
Pages: 508-513
DOI
Related Report
Peer Reviewed
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