| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
When host animals develop lung eosinophilic inflammation by Strongyloides(Sv) infection, the number of group 2 innate lymphoid cells(ILC2) also increase in the lung dependently on IL-33, and sustain even after the expulsion of parasite is completed. If the host infected secondary with other species of nematode(Nb), the residual ILC2s promptly proliferate and produce IL-5 and IL-13 to accumulate and activate eosinophils in the lung, which make the hosts resistant against Nb. This study demonstrates Sv-infected hosts acquire an antigen-nonspecific resistance, which is a benefit for the host animals to live in an area where multiple parasites spread.
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