A role of Loeffler syndrome in Strongyloides-infected mice.
| Project/Area Number |
25460521
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
YASUDA Koubun 兵庫医科大学, 医学部, 講師 (50333539)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自然免疫 / 寄生虫免疫 / 自然リンパ球 / 好酸球性肺炎 / IL-33 / ILC2 / 好酸球 / 腸管寄生線虫 / IL-5 / 感染防御 / 自然型アレルギー |
|---|
| Outline of Final Research Achievements |
When host animals develop lung eosinophilic inflammation by Strongyloides(Sv) infection, the number of group 2 innate lymphoid cells(ILC2) also increase in the lung dependently on IL-33, and sustain even after the expulsion of parasite is completed. If the host infected secondary with other species of nematode(Nb), the residual ILC2s promptly proliferate and produce IL-5 and IL-13 to accumulate and activate eosinophils in the lung, which make the hosts resistant against Nb. This study demonstrates Sv-infected hosts acquire an antigen-nonspecific resistance, which is a benefit for the host animals to live in an area where multiple parasites spread.
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Report
(4 results)
Research Products
(25 results)
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[Book] 炎症と免疫2013
Author(s)
安田好文、中西憲司
Total Pages
100
Publisher
先端医学社
Related Report
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