| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
It is believed that tropism and pathogenicity of rickettsiae largely depend on their abilities of adherence to and growth in their host cells. Among the nine isolates from the ticks in the area where no spotted fever rickettsiosis occur, seven strains are very close to Rickettsia japonica genetically and possess highly cross-reactive antigenicity. Moreover, the abilities of adherence to and growth in the target endothelial cell primary culture are very low comparing to those of pathogenic rickettsiae including R. japonica.
These results are consistent with the fact that no spotted fever patients have been seen in the area but that more than ten percent of the habitat have antibody to R. japonica and propose a new paradigm to the epidemiology of spotted fever.
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