Epidemiologic and pathogenic features of an emerging enteropathogen, Escherichia albertii
| Project/Area Number |
25460539
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Kagoshima University (2015)
University of Miyazaki (2013-2014) |
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Principal Investigator |
OOKA TADASUKE 鹿児島大学, 医歯学域医学系, 講師 (50363594)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Escherichia albertii / ゲノム / 病原性 / 検出系 / 新興下痢症起因菌 / III型分泌機構 / 比較ゲノム解析 / ゲノム解析 / 保菌宿主 |
|---|
| Outline of Final Research Achievements |
Escherichia albertii is an emerging enteropathogen. We developed a nested PCR system to detect E. albertii effectively and directly from feces or environmental samples. To understand the host species distribution of E. albertii, we performed screening from human and animal feces with the system. The screening revealed that E. albertii detected in pig and free-range chicken with an high frequency but not in healthy individual. We also determined the draft genome sequences of 26 E. albertii strains isolated from animal and diarrheal patients and performed robust intra-species and intra-genus genomic comparisons. Our analysis identified the core genome of E. albertii, the accessory genome specific to E. albertii, and a possible core genome of the genus Escherichia. Several unique or notable genetic features of E. albertii have also been identified. These data provide insights into the genomic evolution, adaptation, and virulence mechanisms of E. albertii.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Defining the Genome Features of Escherichia albertii, an Emerging Enteropathogen Closely Related to Escherichia coli2015
Author(s)
Ooka T, Ogura Y, Katsura K, Seto K, Kobayashi H, Kawano K, Tokuoka E, Furukawa M, Harada S, Yoshino S, Seto J, Ikeda T, Yamaguchi K, Murase K, Gotoh Y, Imuta N, Nishi J, Gomes TA, Beutin L, Hayashi T.
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Journal Title
Genome Biol Evol
Volume: 7(12)
Pages: 3170-3179
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage.2015
Author(s)
Yoshitoshi Ogura, Shakhinur Islam Mondal, Md Rakibul Islam, Toshihiro Mako, Kokichi Arisawa, Keisuke Katsura, Tadasuke Ooka, Yasuhiro Gotoh, Kazunori Murase, Makoto Ohnishi, and Tetsuya Hayashi
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 16663-16663
DOI
NAID
Related Report
Peer Reviewed / Open Access
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