| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Escherichia albertii is an emerging enteropathogen. We developed a nested PCR system to detect E. albertii effectively and directly from feces or environmental samples. To understand the host species distribution of E. albertii, we performed screening from human and animal feces with the system. The screening revealed that E. albertii detected in pig and free-range chicken with an high frequency but not in healthy individual. We also determined the draft genome sequences of 26 E. albertii strains isolated from animal and diarrheal patients and performed robust intra-species and intra-genus genomic comparisons. Our analysis identified the core genome of E. albertii, the accessory genome specific to E. albertii, and a possible core genome of the genus Escherichia. Several unique or notable genetic features of E. albertii have also been identified. These data provide insights into the genomic evolution, adaptation, and virulence mechanisms of E. albertii.
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