Development of new steroidal bactericidal substances for Helicobacter pylori

Research Project

Project/Area Number	25460544
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Bacteriology (including mycology)
Research Institution	Jichi Medical University
Principal Investigator	Shimomura Hirofumi 自治医科大学, 医学部, 准教授 (80348002)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	ピロリ菌 / ステロイド / 不飽和脂肪酸 / 飽和脂肪酸 / グリセロリン脂質 / 極狭域スペクトル抗菌薬 / 狭域スペクトル抗癌剤 / プロゲステロン誘導体 / ホスファチジルエタノールアミン / 抗菌作用 / 抗腫瘍作用 / 合成プロゲステロン / 抗菌活性 / 新規ピロリ菌感染症治療薬
Outline of Final Research Achievements	This study demonstrated that new progesterone derivatives selectively act as bactericidal agents on Helicobacter pylori, a pathogen responsible for gastric cancer in human, but have no influence on the survival of other representative bacteria such as enterobacteria. These results indicate that progesterone could be a convenient structure for development of steroidal antibacterial medicines in the eradication of H. pylori in human stomach.