Development of new steroidal bactericidal substances for Helicobacter pylori
| Project/Area Number |
25460544
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ピロリ菌 / ステロイド / 不飽和脂肪酸 / 飽和脂肪酸 / グリセロリン脂質 / 極狭域スペクトル抗菌薬 / 狭域スペクトル抗癌剤 / プロゲステロン誘導体 / ホスファチジルエタノールアミン / 抗菌作用 / 抗腫瘍作用 / 合成プロゲステロン / 抗菌活性 / 新規ピロリ菌感染症治療薬 |
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| Outline of Final Research Achievements |
This study demonstrated that new progesterone derivatives selectively act as bactericidal agents on Helicobacter pylori, a pathogen responsible for gastric cancer in human, but have no influence on the survival of other representative bacteria such as enterobacteria. These results indicate that progesterone could be a convenient structure for development of steroidal antibacterial medicines in the eradication of H. pylori in human stomach.
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Report
(4 results)
Research Products
(3 results)
