Protective immunity against Bordetella holmesii

• Project/Area Number: 25460546
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bacteriology (including mycology)
• Research Institution: Kitasato University
• Principal Investigator: Watanabe Mineo 北里大学, 大学院感染制御科学府, 准教授 (40279245)
• Co-Investigator(Kenkyū-buntansha): KAMACHI Kazunari 国立感染症研究所, 細菌第二部, 室長 (10260275)
• Research Collaborator: SUZUKI Eri ; SAITO Momoko ; YAMAGUCHI Tetsuya
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ワクチン / 百日咳 / 病原性 / Bordetella / 再興感染症 / 新興感染症 / 小児 / 呼吸器 / 診断法 / 免疫 / 感染 / 細菌 / 感染症

Outline of Final Research Achievements

Pertussis (whooping cough) is a highly contagious respiratory disease caused by Bordetella pertussis and Bordetella parapertussis. Recently, Bordetella holmesii has being mentioned as the third causative agent of pertussis. Epidemiological studies clearly suggested importance of control of B. holmesii infection in humans.
In this study, we developed effective vaccines against B. holmesii infection in a mouse model. Also, we determined a protective antigen of B. holmesii. Our results will help development of modified pertussis vaccines that are effective to all causative agents of pertussis.

Research Products

• [Journal Article] 百日咳ワクチン開発の歴史：全菌体ワクチンの開発から無細胞型ワクチンへの転換，これからのワクチン (2015)
  • Author(s): 渡邉峰雄，鈴木英里，齋藤桃子
  • Journal Title: 臨床とウイルス Volume: 43 Pages: 13-16
• [Presentation] BipA is an autoagglutination inhibitor required for biofilm formation in Bordetella holmesii (2016)
  • Author(s): 平松征洋，齋藤桃子，大塚菜緒，渡邉峰雄，柴山恵吾，蒲地一成
  • Organizer: 第89回日本細菌学会総会
  • Place of Presentation: 大阪国際交流センター（大阪府大阪市）
  • Year and Date: 2016-03-24
• [Presentation] Protective effects of Vaccines against Bordetella holmesii in a Mouse Model of Respiratory Infection (2016)
  • Author(s): 齋藤桃子，大塚菜緒，蒲地一成，渡邉峰雄
  • Organizer: 第89回日本細菌学会総会
  • Place of Presentation: 大阪国際交流センター（大阪府大阪市）
  • Year and Date: 2016-03-23
• [Presentation] Development of vaccines against Bordetella holmesii in a murine model of respiratory infection (2015)
  • Author(s): Saito M, Suzuki E, Yamaguchi T, Kamachi K, Watanabe M
  • Organizer: General meeting of American Society for Microbiology
  • Place of Presentation: New Orleans, LA, U.S.A.
  • Year and Date: 2015-06-02
• [Presentation] 百日咳類縁菌Bordetella holmesiiの自己凝集抑制因子BipAに関する研究 (2015)
  • Author(s): 平松征洋，大塚菜緒，柴山惠吾，鈴木英里，渡邉峰雄，蒲地一成
  • Organizer: 第88回日本細菌学会総会
  • Place of Presentation: 岐阜県岐阜市
  • Year and Date: 2015-03-26
• [Presentation] 国内で分離されたBordetella holmesiiに対する百日咳ワクチンの効果
  • Author(s): 山口哲矢、渡邉峰雄
  • Organizer: 第26回北里大学バイオサイエンスフォーラム
  • Place of Presentation: 相模原市（北里大学）
• [Presentation] Bordetella holmesiiIこ対する無細胞ワクチンの開発
  • Author(s): 山口哲矢、鈴木英里、大塚菜緒、蒲地一成、渡邉峰雄
  • Organizer: 第87回日本細菌学会総会
  • Place of Presentation: 東京（タワーホール船堀）
• [Presentation] Unsolved Problems in Pertussis Control
  • Author(s): Mineo Watanabe, Eri Suzuki, Momoko Saito, Tetsuya Yamaguchi
  • Organizer: The 12th Japan-Korea International Symposium on Microbiology
  • Place of Presentation: 東京（タワーホール船堀）
  • Invited
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