the dynamics of influenza virus infection using animal model
| Project/Area Number |
25460562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kiso Maki 東京大学, 医科学研究所, 特任助教 (00624602)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | インフルエンザ / 抗ウイルス薬 / インフルエンザウイルス |
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| Outline of Final Research Achievements |
In this study, we used nude mice as an immune-compromised model and analyzed the effect of antivirals and the mechanism of antiviral resistance.
We infected nude mice with a mouse adapted A/California/04(pdmH1N1) virus and treated with anti-influenza drug. The virus replicated in the lung of nude mice for a long term regardless with or without antiviral treatment. Though the survival rate of nude mice were improved by long term treatment, drug resistant viruses were frequently appeared by such a treatment. These findings are useful for the better understanding the emergence and properties of antiviral-resistant viruses in clinical settings.
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Report
(4 results)
Research Products
(2 results)
