| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, we used nude mice as an immune-compromised model and analyzed the effect of antivirals and the mechanism of antiviral resistance.
We infected nude mice with a mouse adapted A/California/04(pdmH1N1) virus and treated with anti-influenza drug. The virus replicated in the lung of nude mice for a long term regardless with or without antiviral treatment. Though the survival rate of nude mice were improved by long term treatment, drug resistant viruses were frequently appeared by such a treatment. These findings are useful for the better understanding the emergence and properties of antiviral-resistant viruses in clinical settings.
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