| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The genome of HIV-1 always forms dimer in virion. The genome dimerization is believed to have important roles on viral infectivity and/or pathogenicity. Previously I suggested the dimerization signal region RNA (DLS) of HIV-1 forms pseudoknot-like structure. In this project, I explored a precise functional structures around the pseudoknot, such as SL1 and primer binding site applying virological/molecular biological approach. In addition, I focused on the p1 region, which is important for viral maturation process and examined its roles on viral infectivity and genome packaging.
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