| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Infection with new influenza viruses, for example avian H5N1 virus, is known to have a high mortality rate. The main cause of death among these patients is acute respiratory distress syndrome (ARDS)/diffuse alveolar damage (DAD). However, no effective treatment for ARDS/DAD has been established. We previously reported that i) mouse-adapted influenza virus infection induced ARDS/DAD in the mouse lungs, ii) administration of artificial surfactant had a beneficial effect on mice infected with influenza virus.
In this study, we tried to reveal the mechanism of beneficial effect of the artificial surfactant to influenza virus-infected mice. In addition, the effect of the new type of artificial surfactant was examined.
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