Analysis of the mechanism of severe pneunomia by influenza virus infection

Research Project

Project/Area Number	25460568
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Virology
Research Institution	Hiroshima University
Principal Investigator	Fukushi Masaya 広島大学, 大学院医歯薬保健学研究院(医), 助教 (50313515)
Co-Investigator(Kenkyū-buntansha)	SAKAGUCHI TAKEMASA 広島大学, 大学院医歯薬保健学研究院, 教授 (70196070)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	インフルエンザウイルス感染 / 重症肺炎 / 肺サーファクタント / 治療 / インフルエンザウイルス
Outline of Final Research Achievements	Infection with new influenza viruses, for example avian H5N1 virus, is known to have a high mortality rate. The main cause of death among these patients is acute respiratory distress syndrome (ARDS)/diffuse alveolar damage (DAD). However, no effective treatment for ARDS/DAD has been established. We previously reported that i) mouse-adapted influenza virus infection induced ARDS/DAD in the mouse lungs, ii) administration of artificial surfactant had a beneficial effect on mice infected with influenza virus. In this study, we tried to reveal the mechanism of beneficial effect of the artificial surfactant to influenza virus-infected mice. In addition, the effect of the new type of artificial surfactant was examined.