| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Gut dendritic cells (DC) are distinct from peripheral lymph node DC in terms of their phenotypes and functions. We found that TGF-b, which is an abundant cytokine in the gut, is essential for the conditioning of DC in the gut. We generated conditional knockout mice with DC-specific deletion of type II TGF-b receptor (TbRII-DCKO), and found that TbRII-DCKO mice develop spontaneously autoimmune-like diseases, which are characterized by inflammatory cell migration into several organs and autoantibody production. Interestingly, in TbRII-DCKO mice that had developed the diseases, some commensal bacteria were detected in peripheral lymphoid organs, and the symptom and host survival were partly improved by treatment with antibiotics.
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