Analysis of anti-timor immune responses by costimulatory molecules and application for the clinics

Research Project

Project/Area Number	25460587
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Immunology
Research Institution	Shinshu University
Principal Investigator	SHIN Tahiro 信州大学, 医学部, 非常勤講師 (70637199)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	腫瘍免疫 / 共刺激分子 / 抗腫瘍免疫反応 / がんワクチン / B7-DC / PD-L2
Outline of Final Research Achievements	The standard therapies for cancer have not been effective enough yet. As a new approach, cancer immunotherapy is considered very hopeful. In this project, we analyzed the following mechanism: (1) the biological role of B7-DC in cancer immunoediting (Elimination, Equilibrium, Escape) (2) the immunological role of CD4 T cells for the anti-cancer effect of B7-DC (3) the basic experiments for the development of cancer vaccine utilizing B7-DC. By our experiments, those were confirmed that B7-DC facilitates cancer Elimination, maintain cancer Equilibrium and inhibits cancer Escape. Also, it was suggested that the cells expressing B7-DC induce cancer antigen specific CTLs. It seems very possible that the clinical applications for a new cancer immunotherapy utilizing B7-DC would be established in near future.