| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The standard therapies for cancer have not been effective enough yet. As a new approach, cancer immunotherapy is considered very hopeful. In this project, we analyzed the following mechanism: (1) the biological role of B7-DC in cancer immunoediting (Elimination, Equilibrium, Escape) (2) the immunological role of CD4 T cells for the anti-cancer effect of B7-DC (3) the basic experiments for the development of cancer vaccine utilizing B7-DC. By our experiments, those were confirmed that B7-DC facilitates cancer Elimination, maintain cancer Equilibrium and inhibits cancer Escape. Also, it was suggested that the cells expressing B7-DC induce cancer antigen specific CTLs. It seems very possible that the clinical applications for a new cancer immunotherapy utilizing B7-DC would be established in near future.
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