| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Inflammatory and immune cell migration to inflamed sites is essential for host defense against pathogens, but it also plays a role in the pathogenesis of autoimmune and allergic diseases. In this research project, we investigated molecular mechanisms underlying the migration of various cell subsets to inflamed tissues, and analyzed how cell migration was regulated. We identified a novel isoform of human L-selectin encoding a soluble molecule, implicated in the functional regulation of cell surface L-selectin, which mediates immune cell migration to inflamed sites. We also clarified that selectin ligand modifying enzymes are differentially expressed in the T cell subsets that migrate to the inflamed skin. We further identified candidate molecules involved in memory T cell migration to the nasal mucosa during nasal immune responses.
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