Molecular mechanisms and control of immune cell migration to inflamed sites
| Project/Area Number |
25460588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Hirata Takako 滋賀医科大学, 医学部, 教授 (00346199)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 炎症 / アレルギー / リンパ球 / セレクチン / ケモカイン / 免疫学 |
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| Outline of Final Research Achievements |
Inflammatory and immune cell migration to inflamed sites is essential for host defense against pathogens, but it also plays a role in the pathogenesis of autoimmune and allergic diseases. In this research project, we investigated molecular mechanisms underlying the migration of various cell subsets to inflamed tissues, and analyzed how cell migration was regulated. We identified a novel isoform of human L-selectin encoding a soluble molecule, implicated in the functional regulation of cell surface L-selectin, which mediates immune cell migration to inflamed sites. We also clarified that selectin ligand modifying enzymes are differentially expressed in the T cell subsets that migrate to the inflamed skin. We further identified candidate molecules involved in memory T cell migration to the nasal mucosa during nasal immune responses.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis2016
Author(s)
Hasegawa K, Tanaka S, Fujiki F, Morimoto S, Nakano K, Kinoshita H, Okumura A, Fujioka Y, Urakawa R, Nakajima H, Tatsumi N, Nakata J, Takashima S, Nishida S, Tsuboi A, Oka Y, Oji Y, Miyoshi E, Hirata T, Kumanogoh A, Sugiyama H, Hosen N.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prostaglandin E2 promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase2013
Author(s)
Yao, C., Hirata, T., Soontrapa K., Ma, X., Takemori, H., and Narumiya, S
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Journal Title
Nature Communications
Volume: 4
Pages: 1685-1685
DOI
Related Report
Peer Reviewed
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