| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
The role of epigenetic regulation, which establishes and maintains semi-stable gene expression pattern without changes in DNA sequence, in T cell differentiation and function was investigated. When Eed, a gene encoding epigenetic factor involved in histone H3 methylation, was deleted specifically in T cells, proteins associated with a subset of gut IEL (intraepithelial lymphocytes) were highly induced by TGFbeta stimulation in CD4+ T cells. Moreover, the lymphocyte number in gut-affiliated lymphnode increased significantly. These results indicated that epigenetic regulation in T cells is involved in the homeostasis of gut immune system.
|
