Studies on nuclear signaling proteins required for T cell development
| Project/Area Number |
25460606
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo (2014-2015)
独立行政法人国立国際医療研究センター (2013) |
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Principal Investigator |
Nitta Takeshi 東京大学, 医学(系)研究科(研究院), 准教授 (30373343)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Toshiyuki 国立国際医療研究センター, 研究所, 研究員 (10607328)
TAMEHIRO Norimasa 国立国際医療研究センター, 研究所, 上級研究員 (80597881)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | T細胞 / 胸腺 / TCR / シグナル伝達 / 核 / Themis / Grb2 / 免疫学 / 制御性T細胞 |
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| Outline of Final Research Achievements |
Themis is a newly identified protein that localizes in cytoplasm and nucleus and is essential for inducing T cell development in the thymus. Here we found that Themis binds the adaptor protein Grb2 in the nuclei of T cells and regulates nuclear protein levels of Grb2 in T cells, and that nuclear Themis-Grb2 interaction is required for T cell development. However, the nuclear localization of Themis is dispensable for cytokine production by peripheral T cells, suggesting that Themis has different functions in the thymus and periphery. Our results also show that two CABIT domains in Themis are both required for T cell development and that each of the CABIT domains exerts distinct functions during T cell development.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gdT cells.2015
Author(s)
Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata T, Suzuki H.
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Journal Title
EMBO Rep.
Volume: なし
Issue: 5
Pages: 638-653
DOI
Related Report
Peer Reviewed
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