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Economic evaluation of diagnostic technologies supporting tailor-made decision in breast cancer treatment

Research Project

Project/Area Number 25460610
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical sociology
Research InstitutionUniversity of Tsukuba

Principal Investigator

Kondo Masahide  筑波大学, 医学医療系, 准教授 (70334068)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords乳がん / 個別化医療 / 診断技術 / 経済評価
Outline of Final Research Achievements

As an economic evaluation of tailor-made diagnostic technologies for breast cancer care, a cost-effectiveness study was conducted regarding an introduction of the 95-gene assay for the primary breast cancer into the benefit package of the National Health Insurance. The assay was targeted because it had been developed to the stage of diffusion in Japan. Changes of the treatment decision whether undergoing adjuvant chemotherapy or not according to validation case series for the development of the assay were applied for an economic Markov model of breast cancer care. An incremental cost-effectiveness ratio of including the assay into the benefit package was estimated at \4,754,269 in order to gain 1 quality adjusted life year. It was less than the threshold of social willingness-to-pay for new health care, \5,000,000, which suggested that making the assay available under the National Health Insurance was justifiable.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] Survival of HER2-positive primary breast cancer patients treated by neoadjuvant chemotherapy plus trastuzumab: a multicenter retrospective observational study (JBCRG-C03 study).2014

    • Author(s)
      Takada M, Ishiguro H, Nagai S, Ohtani S, Kawabata H, Yanagita Y, Hozumi Y, Shimizu C, Takao S, Sato N, Kosaka Y, Sagara Y, Iwata H, Ohno S, Kuroi K, Masuda N, Yamashiro H, Sugimoto M, Kondo M, Naito Y, Sasano H, Inamato T, Morita S, Toi M on behalf of the JBCRG-C03 Collaborative Group.
    • Journal Title

      Breast Cancer Res Treat

      Volume: Volume 145, Issue 1 Issue: 1 Pages: 143-53

    • DOI

      10.1007/s10549-014-2907-9

    • NAID

      120005627665

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 医療経済-多遺伝子アッセイの経済評価例-2013

    • Author(s)
      近藤正英
    • Journal Title

      乳癌の臨床

      Volume: 28 Pages: 365-373

    • Related Report
      2013 Research-status Report
  • [Presentation] Predictive factors for pathologic complete response and disease-free survival after neoadjuvant chemotherapy with trastuzumab: A multicenter retrospective observational study in patients with HER2-positive primary breast cancer (JBCRG-C03 study)2013

    • Author(s)
      Takada M, Ishiguro H, Nagai S, Ohtani S, Kawabata H, Yanagita Y, Hozumi Y, Shimizu C, Takao S, Sato N, Kosaka Y, Sagara Y, Iwata H, Ohno S, Kuroi K, Masuda N, Yamashiro H, Sugimoto M, Kondo M, Naito Y, Sasano H, Inamoto T, Morita S, Toi M.
    • Organizer
      The 2013 San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio, TX, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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