Real-world feedback from the multicenter regitsry (KiCS) for invasive cardiovascular procedrures.

• Project/Area Number: 25460630
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical sociology
• Research Institution: Keio University
• Principal Investigator: Kohsaka Shun 慶應義塾大学, 医学部, 講師 (30528659)
• Co-Investigator(Renkei-kenkyūsha): Ueda Ikuko 慶應義塾大学, 医学部, 特任助教 (80571398) ; Miyata Hiroaki 東京大学, 医療品質評価学, 教授 (70409704)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 冠動脈インターベンション / 医療の質 / 適切性基準 / データベース / レジストリ / アウトカム研究 / 大規模データベース / レジストリ研究 / 冠動脈疾患 / アウトカム

Outline of Final Research Achievements

The aim of this study was to evaluate the appropriateness of percutaneous coronary intervention (PCI) in Japan and clarify the association between trends of pre-procedural noninvasive testing and changes in appropriateness ratings. In this contemporary, multicenter Japanese PCI registry　(JCD-KiCS), almost all acute PCIs were acceptable regardless of the criteria applied. However, approximately one-sixth of nonacute PCIs were rated as inappropriate under the original criteria. Under the updated AUC/2012, the rate of inappropriate PCIs increased to nearly one-third because noninvasive stress testing was not performed before a large number of elective PCIs in Japan and was seemingly affected by the increasing trend of coronary CT angiogram.

Research Products

• [Int'l Joint Research] Department of Cardiology/Univeristy of Colorado, Denver, CO(米国)
• [Int'l Joint Research] Mid America Heart Institute/Kansas City, KA(米国)
• [Journal Article] Performance and validation of the U.S. National Cardiovascular Data Registry acute kidney injury prediction model in Japan. (2016)
  • Author(s): Inohara T, Kohsaka S, Miyata H, Ueda I, Maekawa Y, Fukuda K, Cohen DJ, Kennedy KF, Rumsfeld JS, Spertus JA.
  • Journal Title: J Am Coll Cardiol Volume: 67 Issue: 14 Pages: 1715-22
  • DOI: 10.1016/j.jacc.2016.01.049
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Temporal Trends in Percutaneous Coronary Intervention Appropriateness: Insights From the Clinical Outcomes Assessment Program. (2016)
  • Author(s): Inohara T, Kohsaka S, Fukuda K.
  • Journal Title: Circulation Volume: 133 Issue: 9
  • DOI: 10.1161/circulationaha.115.018106
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of Preoperative β-Blocker Use on Clinical Outcomes after Coronary Artery Bypass Grafting.A Report from the Japanese Cardiovascular Surgery Database (2015)
  • Author(s): Kohsaka S, Miyata H, Motomura N, Imanaka K, Fukuda K, Kyo S, Takamoto S
  • Journal Title: Anesthesiology Volume: 124 Issue: 1 Pages: 45-55
  • DOI: 10.1097/aln.0000000000000901
  • Peer Reviewed
• [Journal Article] Use of Intra-aortic Balloon Pump in a Japanese Multicenter Percutaneous Coronary Intervention Registry. (2015)
  • Author(s): Inohara T, Miyata H, Ueda I, Maekawa Y, Fukuda K, Kohsaka S.
  • Journal Title: JAMA Internal Medicine Volume: 124 Issue: 12 Pages: 1980-2
  • DOI: 10.1001/jamainternmed.2015.5119
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An international comparison of patients undergoing percutaneous coronary intervention: A collaborative study of the National Cardiovascular Data Registry (NCDR) and Japan Cardiovascular Database-Keio interhospital Cardiovascular Studies (JCD-KiCS). (2015)
  • Author(s): Kohsaka S, Miyata H, Ueda I, Masoudi FA, Peterson ED, Maekawa Y, Kawamura A, Fukuda K, Roe MT, Rumsfeld JS
  • Journal Title: Am Heart Journal Volume: 170 Issue: 6 Pages: 1077-85
  • DOI: 10.1016/j.ahj.2015.09.017
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Outcomes of Percutaneous Coronary Intervention Performed With or Without Preprocedural Dual Antiplatelet Therapy (2015)
  • Author(s): Ikegami Y, Kohsaka S, Miyata H, Ueda I, Fuse J, Sakamoto M, Shiraishi Y, Numasawa Y, Negishi K, Nakamura I, Maekawa Y, Momiyama Y, Fukuda K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 12 Pages: 2598-2607
  • DOI: 10.1253/circj.CJ-15-0484
  • NAID: 130005110917
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Prevalence of Clinically Significant Ischemia in Patients Undergoing Percutaneous Coronary Intervention: A Report from the Multicenter Registry. (2015)
  • Author(s): Fujita J, Kohsaka S, Ueda I, Inohara T, Maekawa Y, Kawamura A, Kanazawa H, Hayashida K, Tabei R, Tohyama S, Seki T, Suzuki M, Sano M, Fukuda K. T
  • Journal Title: PLoS One Volume: 10 Issue: 7 Pages: e0133568-e0133568
  • DOI: 10.1371/journal.pone.0133568
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Real-World Use and Appropriateness of Coronary Interventions for Chronic Total Occlusion (from a Japanese Multicenter Registry). (2015)
  • Author(s): Inohara T, Kohsaka S, Miyata H, Ueda I, Hayashida K, Maekawa Y, Kawamura A, Numasawa Y, Suzuki M, Noma S, Nishi Y, Fukuda K.
  • Journal Title: Am J Cardiol. Volume: 116 Issue: 6 Pages: 858-64
  • DOI: 10.1016/j.amjcard.2015.06.008
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Angiographic Lesion Complexity Score and In-Hospital Outcomes after Percutaneous Coronary Intervention. (2015)
  • Author(s): Endo A, Kawamura A, Miyata H, Noma S, Suzuki M, Koyama T, Ishikawa S, Nakagawa S, Takagi S, Numasawa Y, Fukuda K, Kohsaka S
  • Journal Title: PLoS One Volume: 10 Issue: 6 Pages: e0127217-e0127217
  • DOI: 10.1371/journal.pone.0127217
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hypothesis of Long-Term Outcome after Coronary Revascularization in Japanese Patients Compared to Multiethnic Groups in the US. (2015)
  • Author(s): Inohara T, Kohsaka S, Goto M, Furukawa Y, Fukushima M, Sakata R, Elayda M, Wilson JM, Kimura T. Hypothesis of Long-Term Outcome after Coronary Revascularization in Japanese Patients Compared to Multiethnic Groups in the US.
  • Journal Title: PLoS One Volume: 10 Issue: 5 Pages: e0128252-e0128252
  • DOI: 10.1371/journal.pone.0128252
  • NAID: 120005947132
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Location of the Culprit Coronary Lesion and Its Association With Delay in Door-to-Balloon Time (from a Multicenter Registry of Primary Percutaneous Coronary Intervention). (2015)
  • Author(s): Kuno T, Kohsaka S, Numasawa Y, Ueda I, Suzuki M, Nakamura I, Negishi K, Ishikawa S, Maekawa Y, Kawamura A, Miyata H, Fukuda K.
  • Journal Title: Am J Cardiol. Volume: 115 Issue: 5 Pages: 581-6
  • DOI: 10.1016/j.amjcard.2014.12.004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Gender differences in in-hospital clinical outcomes after percutaneous coronary interventions: an insight from a Japanese multicenter registry. (2015)
  • Author(s): Numasawa Y, Kohsaka S, Miyata H, Noma S, Suzuki M, Ishikawa S, Nakamura I, Nishi Y, Ohki T, Negishi K, Takahashi T, Fukuda K.
  • Journal Title: PLoS One. Volume: 10 Issue: 1 Pages: e0116496-e0116496
  • DOI: 10.1371/journal.pone.0116496
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Frequency and safety of intracoronary acetylcholine provocation testing compared to coronary interventions: Analysis of a contemporary Japanese multicenter PCI registry. (2015)
  • Author(s): Kohno T, Kohsaka S, Ueda I, Noma S, Suzuki M, Numasawa Y, Akaishi M, Maekawa Y, Miyata H, Fukuda K.
  • Journal Title: Int J Cardiol. Volume: 183 Pages: 171-2
  • DOI: 10.1016/j.ijcard.2015.01.064
• [Journal Article] Radial coronary interventions and post-procedural complication rates in the real world: a report from a Japanese multicenter percutaneous coronary intervention registry. (2014)
  • Author(s): Mizuno A, Kohsaka S, Miyata H, Koide K, Asano T, Ohki T, Negishi K, Fukuda K, Nishi Y.
  • Journal Title: Int J Cardiol. Volume: 172 Issue: 1 Pages: 226-7
  • DOI: 10.1016/j.ijcard.2013.12.225
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prognostic implication of physical signs of congestion in acute heart failure patients and its association with steady-state biomarker levels. (2014)
  • Author(s): Negi S, Sawano M, Kohsaka S, Inohara T, Shiraishi Y, Kohno T, Maekawa Y, Sano M, Yoshikawa T, Fukuda K.
  • Journal Title: PLoS One Volume: 6;9(5) Issue: 5 Pages: e96325-e96325
  • DOI: 10.1371/journal.pone.0096325
  • Peer Reviewed / Open Access
• [Journal Article] Incidence and prognostic significance of myocardial late gadolinium-enhancement in sarcoidosis patients without cardiac manifestation. (2014)
  • Author(s): Nagai T, Kohsaka S, Okuda S, Anzai T, Asano K, Fukuda K.
  • Journal Title: Chest Volume: 146 Issue: 4 Pages: 1064-1072
  • DOI: 10.1378/chest.14-0139
  • Peer Reviewed / Open Access
• [Journal Article] Attitudes of early-career cardiologists in Japan about their cardiovascular training programs. (2014)
  • Author(s): Kohno T, Kohsaka S, Ohshima K, Takei Y, Yamashina A, Fukuda K.
  • Journal Title: Am J Cardiol. Volume: 114 Issue: 4 Pages: 629-34
  • DOI: 10.1016/j.amjcard.2014.05.046
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Appropriateness ratings of percutaneous coronary intervention in Japan and its association with the trend of noninvasive testing. (2014)
  • Author(s): Inohara T, Kohsaka S, Miyata H, Ueda I, Ishikawa S, Ohki T, Nishi Y, Hayashida K, Maekawa Y, Kawamura A, Higashi T, Fukuda K.
  • Journal Title: JACC Cardiovasc Interv. Volume: 7 Issue: 9 Pages: 1000-9
  • DOI: 10.1016/j.jcin.2014.06.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Appropriateness of coronary interventions in Japan by the US and Japanese standards. (2014)
  • Author(s): Inohara T, Kohsaka S, Miyata H, Ueda I, Noma S, Suzuki M, Negishi K, Endo A, Nishi Y, Hayashida K, Maekawa Y, Kawamura A, Higashi T, Fukuda K.
  • Journal Title: Am Heart J. Volume: 168 Issue: 6 Pages: 854-61
  • DOI: 10.1016/j.ahj.2014.08.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Impact of periprocedural bleeding on incidence of contrast-induced acute kidney injury in patients treated with percutaneous coronary intervention. (2013)
  • Author(s): Ohno Y, Maekawa Y, Miyata H, Inoue S, Ishikawa S, Sueyoshi K, Noma S, Kawamura A, Kohsaka S, Fukuda K.
  • Journal Title: J Am Coll Cardiol. Volume: 62(14) Issue: 14 Pages: 1260-6
  • DOI: 10.1016/j.jacc.2013.03.086
• [Journal Article] Disparity in the application of guideline - based medical therapy after percutaneous coronary intervention : analysis from the Japanese prospective multicenter registry (2013)
  • Author(s): Endo A, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyama T, Ishikawa S, Momiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Sato Y, Ogawa S, Fukuda K
  • Journal Title: Am J Cardiovasc Drugs Volume: 13(2) Issue: 2 Pages: 103-12
  • DOI: 10.1007/s40256-013-0021-8
  • Peer Reviewed
• [Presentation] Disparity in the application of secondary prevention drugs after percutaneous coronary intervention: An insight from the Japanese multicenter registry (2016)
  • Author(s): 香坂 俊
  • Organizer: 第80回 日本循環器学会学術集
  • Place of Presentation: 仙台市民会館（宮城県仙台市）
  • Year and Date: 2016-03-18
  • Int'l Joint Research
• [Presentation] 循環器内科医の薬剤選択－現場の医師は何を考え、どう処方するのか？－ (2015)
  • Author(s): 香坂 俊
  • Organizer: 第25回 日本医療薬学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-11-21
  • Int'l Joint Research / Invited
• [Presentation] シンポジウム 胸部心臓血管外科領域における臨床研究：現状と将来展望 「大規模レジストリを基礎としたmultidisciplinary approach」 (2015)
  • Author(s): 香坂 俊
  • Organizer: 第68回 日本胸部外科学会定期学術集会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2015-10-20
  • Int'l Joint Research / Invited
• [Presentation] シンポジウム 「安定狭心症の診断を再考する： 我が国の術前評価の現状と国際的な適切性基準との照合」 (2015)
  • Author(s): 香坂 俊
  • Organizer: 第63回 日本心臓病学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-09-20
  • Int'l Joint Research / Invited
• [Presentation] Symposium: CVIT peer review for appropriate PCI 「Quality assessment for coronary interventions: Insights from Japanese multicenter PCI Registries」 (2015)
  • Author(s): 香坂 俊
  • Organizer: 第24回 日本心血管インターベンション治療学会
  • Place of Presentation: 福岡国際会議場（福岡県博多市）
  • Year and Date: 2015-08-01
  • Int'l Joint Research / Invited
• [Presentation] The strength of the large scale registry studies in Japan compared with international datasets, and its health care policy implications (2015)
  • Author(s): 香坂 俊
  • Organizer: 第79回 日本循環器学会学術集会
  • Place of Presentation: 大阪・大阪国際会議場
  • Year and Date: 2015-04-24
• [Presentation] J-PCI（日本心血管インターベンション治療学会）レジストリの歩み (2014)
  • Author(s): 香坂 俊
  • Organizer: 第28回 日本冠疾患学会学術集会
  • Place of Presentation: 東京・ステーションコンファレンス東京
  • Year and Date: 2014-12-12
  • Invited
• [Presentation] The appropriateness ratings of percutaneous coronary intervention in Japan and its association with the trend of non-invasive testings (2014)
  • Author(s): 猪原 拓 香坂 俊
  • Organizer: 第62回 日本心臓病学会学術集会
  • Place of Presentation: 仙台・仙台国際センター
  • Year and Date: 2014-09-26
• [Presentation] 手技ベースの大規模レジストリから見えてきた我が国の冠動脈再建術の動向 (2014)
  • Author(s): 香坂 俊
  • Organizer: 第46回 日本動脈硬化学会 総会・学術集会
  • Place of Presentation: 東京・京王プラザホテル
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] Why is UDI important? – 国際共同レジストリとUnique Device Identifier (2014)
  • Author(s): 香坂 俊
  • Organizer: 第159回 レギュラトリーサイエンスエキスパート研修会
  • Place of Presentation: 東京・日本薬学会長井記念館
  • Year and Date: 2014-06-30
  • Invited
• [Presentation] Unique Characteristics of PCI in Japan and Its Implication in Selecting Revascularization Strategies (2014)
  • Author(s): Shun Kohsaka, Hiroaki Miyata, Ikuko Ueda, Akio Kawamura, Keiichi Fukuda
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京有楽町フォーラム
• [Presentation] Constructing a Successful Multicenter Registry in Japan: Overcoming the Hurdles with Internet Technology and Skilled CRCs (2014)
  • Author(s): Ikuko Ueda, Shun Kohsaka, Akio Kawamura, Koichiro Sueyoshi, Shigetaka Noma, Masahiro Suzuki, Yukihiko Momiyama, Susumu Nakagawa, Takashi Koyama, Yutaka Okada, Shiro Ishikawa, Takahiro Ohki, Toshiyuki Takahashi, Yutaro Nishi, Iwao Nakamura, Shunsuke Takagi, Koji Negishi, Takashi Matsubara, Soshin Inoue, Keiichi Fukuda
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京有楽町フォーラム
• [Presentation] What can We Do during Percutaneous Coronary Intervention to Prevent Contrast-Induced Acute Kidney Injury? (2014)
  • Author(s): Yuichiro Maekawa, Shun Kohsaka, Yohei Ohno, Hiroaki Miyata, Soushin Inoue, Shiro Ishikawa, Koichiro Sueyoshi, Shigetaka Noma, Kentaro Hayashida, Akio Kawamura, Keiichi Fukuda
  • Organizer: 第78回日本循環器学会
  • Place of Presentation: 東京有楽町フォーラム