| Project/Area Number |
25460647
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | University of Toyama |
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Principal Investigator |
Okabe Motonori 富山大学, 大学院医学薬学研究部(医学), 助教 (60283066)
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| Co-Investigator(Kenkyū-buntansha) |
吉田 淑子 富山大学, 大学院医学薬学研究部(医学), 准教授 (00171421)
相古 千加 富山大学, 大学院医学薬学研究部(医学), 助教 (10523889)
二階堂 敏雄 富山大学, 学内共同利用施設等, 理事・副学長 (50180568)
野村 義宏 東京農工大学, 農学部, 教授 (10228372)
林 京子 中部大学, 付置研究所, 研究員 (60110623)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUTA SYOUSHI 福井県立大学, 生物資源学, 准教授 (30254246)
DOKI YOSHINORI 富山大学, 大学院医学薬学研究部(医学), 講師 (90303221)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ヒト組織利用研究 / ハイパードライヒト乾燥羊膜 / 抗生物質 / 抗菌効果 / 定量 / 国際特許 / ウイルス不活化 / ヒト乾燥羊膜 |
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| Outline of Final Research Achievements |
The human amniotic membrane (AM) has been widely used in ophthalmic surgery. However, it has never been explored that AM is effective for the release of impregnated drugs.
Hyperdry-AM (HD-AM), glutaraldehyde cross-linked HD-AM (Glu HD-AM) and a solvent of poly-N-p-vinylbenzyl-D-lactonamide (PVLA) were all found not to cause irritation to the rabbit eye. Residual glutaraldehyde in Glu HD-AM was about 40 ppm (dry-weight basis). HD-AM (ACV/PVLA HD-AM) loaded Acyclovir (ACV; hydrophobic medicine) containing PVLA-bearing nanospheres (ACV/PVLA) was more effective against a herpes simplex virus-1 (HSV-1) eye infection model and its efficacy was dose- and volume-dependent.
A combination of HD-AM and PVLA can be working as drug delivery system that may be possible to controlle the release of hydrophobic medicines.
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