A novel pathological mechanism of Alzheimer's disease as a chronic inflammation through RAGE signal activity.
| Project/Area Number |
25460649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIBORI MASAHIRO 岡山大学, 大学院医歯薬学総合研究科, 教授 (50135943)
TERADA SEISHI 岡山大学, 大学院医歯薬学総合研究科, 准教授 (20332794)
LIU KEYUE 岡山大学, 大学院医歯薬学総合研究科, 助教 (40432637)
WAKE HIDENORI 岡山大学, 大学院医歯薬学総合研究科, 助教 (60570520)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | アルツハイマー / アミロイドβ / RAGE / AGE / 慢性炎症 / 神経 / ミクログリア / アストロサイト / 炎症 / 神経細胞 |
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| Outline of Final Research Achievements |
Alzheimer's disease (AD), which is considered that the main pathology is caused by accumulation of amyloid β in the brain, may have an aspect as chronic inflammation disease. We validated a novel mechanism of AD pathology that an inflammatory reaction through the receptor of advanced glycation end products (RAGE) is synergistically enhanced by increased amyloid β and anti-RAGE autoantibody in AD patients. Increased antibody titer against RAGE was shown in plasma of the AD patients, while an enhancements of immunoreactivity and an amyloid β binding to leukocytes were not detected in the AD patients. In future, we will evaluate whether examine plasma levels of the inflammatory factors are up-regulated or not in AD patients.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Glycyrrhizin inhibits traumatic brain injury by reducing HMGB1-RAGE interaction.2014
Author(s)
OkumaY, Liu K, Wake H, Liu R, Nishimura Y, Zhong H, Teshigawara K, Haruma J, Yamamoto Y, Yamamoto H, Date I, Takahashi HK, Mori S, Nishibori M.
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Journal Title
Neuropharmacology
Volume: 85
Pages: 18-26
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Histidine-rich glycoprotein prevents septic lethality through neutrophil regulation.2014
Author(s)
Masahiro Nishibori, Hidenori Wake, Shuji Mori, Keyue Liu, Yuta Morioka, Kiyoshi Teshigawara, Masakiyo Sakaguchi, Kosuke Kuroda, Hideo Takahashi, Aiji Ohtsuka, Tadashi Yoshino, Hiroshi Morimatsu
Organizer
Sepsis Symposium
Place of Presentation
France, Paris, Pasteur Institute
Year and Date
2014-12-03 – 2014-12-05
Related Report
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