• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Roles of endothelium-derived hyperpolarizing factor to reduce intimal hyperplasia

Research Project

Project/Area Number 25460655
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied pharmacology
Research InstitutionNagoya City University

Principal Investigator

ITOH Takeo  名古屋市立大学, 大学院医学研究科, 研究員 (70159888)

Co-Investigator(Kenkyū-buntansha) 梶栗 潤子  名古屋市立大学, 大学院医学研究科, 研究員 (10444986)
Research Collaborator OTSUKA Ryo  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords内皮由来膜過分極因子 / 内膜肥厚 / 静脈グラフト / 動脈グラフト / 血管内皮機能障害 / アセチルコリン / 一酸化窒素 / Ca活性化K+チャネル / 内皮依存性膜過分極因子
Outline of Final Research Achievements

Significant intimal hyperplasia was formed with loss of functions of both endothelium-derived nitric oxide (EDNO) and endothelium-derived hyperpolarizing factor (EDHF) in rabbit autologous jugular vein graft under poor distal runoff. Ezetimibe (a selective cholesterol transport inhibitor) and vildagliptin (a dipeptidyl peptidase-4 inhibitor) each in part recovered the function of EDNO (but not EDHF) and reduced intimal hyperplasia. In contrast, in rabbit autogenous carotid artery graft model, receptor-mediated, endothelium-dependent relaxation was enhanced by increased function of EDNO (but not of EDHF). The intimal thickening was minimal, suggesting that better patency of autogenous arterial graft is considered when compared with that of vein graft in aortocoronary revascularization. These results suggest that upregulation of the EDNO function could be beneficial in reducing intimal hyperplasia in both artery graft and vein graft.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] Enhancement of Nitric Oxide Production Is Responsible for Minimal Intimal Hyperplasia of Autogenous Rabbit Arterial Grafts2017

    • Author(s)
      Tabata K, Komori K, Otsuka R, Kajikuri J, Itoh T.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 8 Pages: 1222-1230

    • DOI

      10.1253/circj.CJ-17-0034

    • NAID

      130005859049

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Dipeptidyl-peptidase 4 inhibitor reduces intimal hyperplasia in rabbit autologous jugular vein graft under poor distal runoff.2015

    • Author(s)
      Koyama A, Komori K, Otsuka R, Kajikuri J, Itoh T
    • Journal Title

      Journal of Vascular Surgery

      Volume: in press Issue: 5 Pages: 1360-70

    • DOI

      10.1016/j.jvs.2014.12.048

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ウサギ正常頸動脈と自家動脈グラフトの内皮依存性弛緩反応 一酸化窒素(NO)と内皮由来過分極因子(EDHF)に注目して2016

    • Author(s)
      田畑 光紀(名古屋大学 血管外科), 秋田 直宏, 藤井 孝之, 山本 規夫, 徳永 晴策, 小山 明男, 前川 卓史, 児玉 章朗, 成田 裕司, 坂野 比呂志, 伊藤 猛雄, 古森 公浩
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] ウサギ自家動脈グラフトと静脈グラフトの内皮機能変化2016

    • Author(s)
      梶栗潤子
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 静脈グラフトに対するビルダグリプチンの効果2015

    • Author(s)
      小山明男
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場 (名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 静脈グラフトと内皮機能2015

    • Author(s)
      伊藤 猛雄, 梶栗 潤子, 古森 公浩
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] ウサギ静脈グラフト血管の内皮依存性弛緩反応に対するビルダグリプチンの作用2015

    • Author(s)
      梶栗 潤子、小山 明男、大塚 亮、古森 公浩、伊藤 猛雄
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] DPP-4阻害薬ビルダグリプチンはウサギ静脈グラフトの内皮機能を改善する2015

    • Author(s)
      伊藤猛雄、小山明男、梶栗潤子、大塚亮、古森公浩
    • Organizer
      第44回日本心脈管作動物質学会
    • Place of Presentation
      高松センタービル(香川県高松市)
    • Year and Date
      2015-02-06 – 2015-02-07
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi