Role of macrophage in renal fibrosis

• Project/Area Number: 25460656
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Osaka City University
• Principal Investigator: Miura Katsuyuki 大阪市立大学, 大学院医学研究科, 教授 (00183624)
• Co-Investigator(Renkei-kenkyūsha): OKA MAYUKO 京都府立大学, 生命環境科学研究科, 准教授 (40347498)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 腎線維化 / マクロファージ / 低酸素

Outline of Final Research Achievements

Monocyte/macrophages play an important role in the pathogenesis of renal fibrosis that is a main determinant that leads to irreversible loss of renal function in chronic kidney disease. However, precise mechanisms by which the activities of infiltrating macrophages are controlled remain to be established. Present study was performed to clarify the role of macrophage hypoxia-inducible factor-1 (HIF-1) in renal fibrosis. We found that macrophage HIF-1 suppresses renal fibrosis but these effects were abolished when renal HIF-1 was totally ablated. These results indicate that roles of HIF-1 in renal fibrosis were different among cells within the kidney.

Research Products

• [Journal Article] Myeloid HIF-1 attenuates the progression of renal fibrosis in murine obstructive nephropathy. (2015)
  • Author(s): Tateishi,Y, Osada-Oka M, Tanaka M, Shiota M, Izumi Y, Ishimura E, Motoyama K, Inaba M, Miura, K.
  • Journal Title: J Pharmacol Sci Volume: 127 Issue: 2 Pages: 181-189
  • DOI: 10.1016/j.jphs.2014.12.011
  • Peer Reviewed / Open Access
• [Presentation] 腎線維化におけるHIF-1の役割 (2016)
  • Author(s): 三浦克之、立石悠、壁井和也、田中昌子、塩田正之、 冨田修平
  • Organizer: 第129回日本薬理学会近畿部会
  • Place of Presentation: 広島医師会館（広島県・広島市）
  • Year and Date: 2016-06-24
• [Presentation] 単球/マクロファージHIF-1の腎線維化における役割 (2014)
  • Author(s): 立石悠、岡真優子、塩田正之、泉康雄、三浦克之
  • Organizer: 第87回日本薬理学会年会
  • Place of Presentation: 仙台国際センター、仙台
• [Presentation] 腎線維化における単球/マクロファージのHIF-1の役割 (2013)
  • Author(s): 立石悠、石村栄治、稲葉雅章、三浦克之
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京国際フォーラム、東京