| Project/Area Number |
25460658
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied pharmacology
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
Fujimura Akio 自治医科大学, 医学部, 教授 (90156901)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ANDO Hitoshi 金沢大学, 医学系, 教授 (50382875)
KOSHIMIZU Takaaki 自治医科大学, 医学部, 准教授 (20392491)
KAKEI Masafumi 自治医科大学, 医学部, 客員教授 (90214270)
SHIGA Tsuyoshi 東京女子医科大学, 医学部, 准教授 (00277211)
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 臨床薬理学 / 循環器 / 薬物有害反応 / QT延長 |
|---|
| Outline of Final Research Achievements |
Bepridil, an anti-arrhythmic drug, has beneficial clinical effects, but causes an adverse effect of QT prolongation leading to sudden cardiac death. In this study, we investigated the effects of alpha-lipoic acid (LA) on bepridil-induced QT prolongation, because LA can protect against arsenic trioxide-induced QT prolongation in guinea pigs. We found that LA dose-dependently attenuates bepridil-induced QT prolongation in guinea pigs, and that LA inhibits the formation of reactive oxygen species in H9c2 myocardial cells. Because alpha-tocopherol, an antioxidant, also attenuated bepridil-induced QT prolongation, LA appears to protect against the adverse effect at least through its antioxidant property.
|
