Protective effects of cilnidipine against hyperuricemia-related renal and vascular injury
| Project/Area Number |
25460662
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
Toba Hiroe 京都薬科大学, 薬学部, 助教 (90351270)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 高尿酸血症 / 臨床薬理学 / hyperuricemia / 高尿酸血漿 |
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| Outline of Final Research Achievements |
This study investigated whether hyperuricemia could induce vascular and renal dysfunction. Administration of an uricase inhibitor potassium oxonate (1500mg/kg/day) increased plasma uric acid levels in uninephrectomized rats (2.7±0.1mg/dL vs. 2.0±0.1mg/dL, p<0.05）. In the hyperuricemia group, urinary protein excretion increased (11±1.2mg/day vs. 7±0.5mg/day, p<0.05) and endothelium-dependent relaxation of the aorta was impaired compared to the vehicle group, whereas there were no significant differences in blood pressure. Cilnidipine had not effect on blood pressure, but decreased plasma uric acid and proteinuria and improved vasodilatory response. These results suggest that the increase in plasma uric acid could be a risk factor for renal and vascular injury. Cilnidipine might be beneficial against renal and vascular dysfunction which relates to hyperuricemia.
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Report
(5 results)
Research Products
(29 results)
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[Presentation] A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN TYPE 1 MOTIF (ADAMTS1) CAUSES RENAL FIBROSIS IN DEOXYCORTICOSTERONE ACETATE-SALT HYPERTENSIVE RATS2017
Author(s)
Hiroe Toba, Tomoka Suzuki, Akari Yoshikawa, Tomoki Noutomi, Yukari Mino, Shiho Ishikawa, Nanako Toda, Kouki Sugino, Naseratun Nessa, Yusuke Watanabe, Miyuki Kobara, Tetsuo Nakata
Organizer
27th European Meeting on Hypertension and Cardiovascular Protection
Place of Presentation
Milan
Year and Date
2017-06-16
Related Report
Int'l Joint Research
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