Development of novel techniques for control and evaluation of the blood-brain barrier based on mechanical and acoustic effects of short-pulsed light
| Project/Area Number |
25460665
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
Sato Shunichi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 准教授 (90502906)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Yasushi 防衛医科大学校, その他部局等, 准教授 (10505267)
KAWAUCHI Satoko 防衛医科大学校, その他部局等, 助教 (20506505)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血液脳関門 / 血液腫瘍関門 / グリオーマ / 薬剤輸送 / フォトメカニカル波 / ナノ秒パルスレーザー / 光音響（断層）イメージング / 光音響イメージング / エバンスブルー / 薬剤分布 |
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| Outline of Final Research Achievements |
We previously found that a pressure wave induced by a short laser pulse, which is called a photomechanical wave, could transiently open the blood-brain barrier. On the basis of this effect, we showed in this study that a drug can safely and efficiently be delivered to the lesion, including infiltrated malignant cells in the peritumoral region, in a rat glioma model; infiltrated malignant cells are associated with the risk of recurrence. We also investigated photoacoustic imaging of the distribution of drug molecules leaked out of the vessels, as well as component technologies needed for the future clinical application of the present drug delivery method.
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Report
(4 results)
Research Products
(40 results)
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[Presentation] Photoacoustic imaging of subcutaneous tumor in mice and its vascular response to photodynamic effect using indocyanine green-labeled biodegradable nanocarrier2015
Author(s)
Y. Tsunoi, S. Sato, R. Watanabe, S. Kawauchi, Y. Miyagawa, D. Mizokami, N. Tanaka, K. Araki, A. Shiotani, E. Ozeki, I. Hara, T. Takemura, M. Terakawa
Organizer
European Conferences on Biomedical Optics 2015
Place of Presentation
Munich, Germany
Year and Date
2015-06-21
Related Report
Int'l Joint Research
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[Presentation] Integrated system for photomechanical drug delivery and photoacoustic imaging of pharmacokinetics2015
Author(s)
Yasuyuki Tsunoi, Shunichi Sato, Ryota Watanabe, Satoko Kawauchi, Yoshihiro Miyagawa, Daisuke Mizokami, Nobuaki Tanaka, Koji Araki, Akihiro Shiotani, Toshiya Takemura, Mitsuhiro Terakawa
Organizer
SPIE Photonics West BiOS 2015
Place of Presentation
The Moscone Center (San Francisco)
Year and Date
2015-02-06 – 2015-02-12
Related Report
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[Presentation] Integrated system for drug delivery and its imaging by the use of nanosecond pulsed laser-induced photomechanical and photoacoustic effects2014
Author(s)
Yasuyuki Tsunoi, Shunichi Sato, Ryota Watanabe, Satoko Kawauchi, Yoshihiro Miyagawa, Daisuke Mizokami, Nobuaki Tanaka, Koji Araki, Akihiro Shiotani, Toshiya Takemura, Mitsuhiro Terakawa
Organizer
Biomedical Molecular Imaging 2014
Place of Presentation
Spa Spring Resort Hotel (Taipei)
Year and Date
2014-11-07
Related Report
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