| Project/Area Number |
25460674
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Chiba University |
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Principal Investigator |
MARUYAMA Hitoshi 千葉大学, 医学(系)研究科(研究院), 講師 (90375642)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Tadashi 千葉大学, フロンティア医工学センター, 教授 (40334172)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肝臓 / 非アルコール性脂肪肝炎 / 脂肪酸 / 超音波 / インピーダンス |
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| Outline of Final Research Achievements |
With the high prevalence of metabolic disorder, nonalcoholic fatty liver disease is increasing worldwide and is emerging as a social problem. Discrimination of nonalcoholic steatohepatitis (NASH) from simple fatty liver by non-invasive and effective approach is the pivotal issue in clinical practice. The current project using 80MHz transducer reports that there is a significant difference in the acoustic property (impedance) in 5 kinds of fatty acid (palmitate, oleate, palmitoleate, linoleate, and α-linolenic acid), tissue color mapping based on the impedance reflects liver disease-related difference, and quantitative assessment of acoustic impedance shows significant difference between normal liver, simple steatosis and NASH with various degrees. These results suggest that acoustic property-based characterization of fatty acids greatly contributes to the improvement of diagnostic ability for fatty liver diseases.
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