Phosphoproteomic analysis of RET kinase signal in MTC model mice
Project/Area Number |
25460682
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
|
Research Institution | Nagoya University |
Principal Investigator |
Kawai Kumi 名古屋大学, 医学系研究科(保健), 准教授 (50362231)
|
Co-Investigator(Kenkyū-buntansha) |
高橋 雅英 名古屋大学, 医学系研究科, 教授 (40183446)
村上 秀樹 愛知医科大学, 医学部, 准教授 (90303619)
|
Research Collaborator |
YAMADA Norika
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | RET / 甲状腺髄様癌 / モデルマウス / プロテオミクス解析 / 分子標的薬 / チロシンキナーゼ阻害剤 / モデル動物 / キナーゼ阻害剤 / 網羅的タンパク質リン酸化解析 / プロテオーム解析 |
Outline of Final Research Achievements |
We examined the effect of multi-kinase inhibitor Sunitinib on MEN2A-RET thyroid medullary carcinoma cells, and Sunitinib presented remarkable inhibition of cell growth, migration and phosphorylation of down stream signaling molecules. Oral administration of Sunitinib to MoMuLV/RET-MEN2A mice exhibited significant tumor regression suggesting the promising effect of Sunitinib on MEN2A patients. LC/MS analysis on thyroid carcinoma tissue of MoMuLV/RET-MEN2A mice presented various interesting phosphotyrosine-binding proteins, and further analysis is required to elucidate the significance of these proteins in thyroid carcinogenesis.
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Report
(5 results)
Research Products
(13 results)
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[Presentation] 切片厚が乳癌HER2免疫染色に及ぼす影響2016
Author(s)
高須大輔, 新免望, 竹内優里, 宮地絵理, 宮川純奈, 加藤衣央, 佐藤浩司, 鈴木利明, 橋本克訓,川井久美
Organizer
第11回日本臨床検査学教育学会学術大会
Place of Presentation
神戸
Year and Date
2016-09-01
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Author(s)
川井久美
Organizer
第104回日本病理学会総会
Place of Presentation
名古屋国際会議場
Year and Date
2015-04-30 – 2015-05-02
Related Report
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