Analysis of mRNA level of the treatment resistance related proteins in unfixed lung cancer biopsy specimens obtained by core-biopsy.
| Project/Area Number |
25460691
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
NAKAMURA Yoichi 長崎大学, 医歯薬学総合研究科(医学系), 講師 (20432974)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAGASHIMA Seiji 長崎大学, 病院(医学系), 助教 (00646672)
FUKUDA Minoru 長崎大学, 病院(医学系), 准教授 (50388930)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 非小細胞肺癌 / 個別化治療 / 個別化医療 / 肺癌化学療法 |
|---|
| Outline of Final Research Achievements |
Total mRNAs were extracted from unfixed lung cancer biopsy specimens, and each RNA level was analyzed. They are compared as ΔCT. ABC transporters; Overexpression was shown in MDR1, MRP1, BCRP. Cytoskeleton proteins; Overexpression was shown in TUBB3, and mild down regulation was shown in Gelsolin. Vascular endothelial growth factors: mild overexpression was shown in VEGF-A and VEGF-B, and overexpression was shown in VEGF-C. Cancer stem cell related antigens: Overexpression was shown in CD20, POU5F1, PROM1, Nanog, KLF4, Notch1, but CD24 and CD44 were no change.
|
Report
(4 results)
Research Products
(8 results)
-
[Journal Article] Chemotherapy2015
Author(s)
Kasai T, Nakamura Y, Fukuda M, Kitazaki T, Nagashima S, Takatani H, Nakano H, Nakatomi K, Ikeda T, Yamaguchi H, Tsukamoto K, Oka M, Kohno S.
-
Journal Title
Phase II study of S-1 for previously untreated elderly patients with advanced non-small cell lung cancer.
Volume: 61
Issue: 2
Pages: 93-98
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Heterogeneity of EGFR mutations in a patient treated with gefitinib as neo-adjuvant chemotherapy.2015
Author(s)
Mizoguchi K, Nakamura Y, Abe K, Takemoto S, Motoshima K, Ogawara D, Nakatomi K, Fukuda M, Fukuoka J, Kohno, S.
-
Journal Title
Cancer Treat Commun
Volume: 4
Pages: 117-120
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
