| Project/Area Number |
25460691
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAKAMURA Yoichi 長崎大学, 医歯薬学総合研究科(医学系), 講師 (20432974)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASHIMA Seiji 長崎大学, 病院(医学系), 助教 (00646672)
FUKUDA Minoru 長崎大学, 病院(医学系), 准教授 (50388930)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 非小細胞肺癌 / 個別化治療 / 個別化医療 / 肺癌化学療法 |
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| Outline of Final Research Achievements |
Total mRNAs were extracted from unfixed lung cancer biopsy specimens, and each RNA level was analyzed. They are compared as ΔCT. ABC transporters; Overexpression was shown in MDR1, MRP1, BCRP. Cytoskeleton proteins; Overexpression was shown in TUBB3, and mild down regulation was shown in Gelsolin. Vascular endothelial growth factors: mild overexpression was shown in VEGF-A and VEGF-B, and overexpression was shown in VEGF-C. Cancer stem cell related antigens: Overexpression was shown in CD20, POU5F1, PROM1, Nanog, KLF4, Notch1, but CD24 and CD44 were no change.
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