Function analysis of circulating tumor cells using a microfluid chip for colorectal cancer.
Project/Area Number |
25460700
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory medicine
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Research Institution | Juntendo University |
Principal Investigator |
Tomiki Yuichi 順天堂大学, 医学部, 准教授 (40245725)
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Co-Investigator(Kenkyū-buntansha) |
ONAGA TAKASHI 富山県工業技術センター, 中央研究所材料技術課, 研究員 (10416133)
KOMIYAMA HIROMITSU 順天堂大学, 医学部, 講師 (30348982)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
Keywords | 血中循環癌細胞 / マイクロ流体チップ / 大腸がん / CTC捕捉システム / 腫瘍マーカー / CTC / 循環腫瘍細胞 / CTCチップ / CTC補足システム |
Outline of Final Research Achievements |
Circulating tumor cells (CTCs) survived in blood and /or tissues distant from these origins are considered to be responsible for distant metastasis of cancers. It is not easy to detect CTCs because of their extremely low concentration in blood, however. We aimed at the establishment of a CTC capturing system for colorectal cancer with a microfluid chip (CTC-chip), a newly-developed device, made by a polymer. In blood samples collected from colorectal cancer patients before surgery, CTCs were detected at high rates with the CTC-chip which had been treated with the monoclonal antibody against epithelial cell adhesion molecule (EpCAM).Then the detection rates of CTCs by this device were significantly higher than positive rates by existing tumor markers, CEA or CA19-9. This novel system should be powerful and convenient for cancer diagnosis especially in early stages and might make CTCs a prognostic factor of colorectal cancer.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Single-Incision Laparoscopic Colostomy or Ileostomy for Unresectable Colorectal Cancer2015
Author(s)
Kawai M, Sakamoto K, Tomiki Y,Okuzawa A, Goto M, Kojima Y, Takahashi M, Komiyama H, Sugimoto K, Ishiyama S, Niwa K, Tashiro Y, Munakata S, Takehara K
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Journal Title
Juntendo Medical Journal
Volume: 61
Issue: 2
Pages: 153-157
DOI
NAID
ISSN
2187-9737, 2188-2126
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] A Case of Clear Cell Adenocarcinoma Arising from Endometriosis of the Rectum Treated by Laparoscopic Surgery2014
Author(s)
Yu Okazawa, Rina Takahashi, Kosuke Mizukoshi, Kazuhiro Takehara, Shun Ishiyama, Kiichi Sugimoto, Makoto Takahashi, Yutaka Kojima, michitoshi Goto, Atsushi Okuzawa, Yuichi Tomiki, Takashi Yao, Kazuhiro Sakamoto
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Journal Title
International Journal of Surgery Case Report
Volume: 5
Pages: 979-983
Related Report
Peer Reviewed / Open Access
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[Journal Article] An effective 5-fluorouracil, levofolinate, and oxaliplatin therapy for recurrent breast cancer: a case report2014
Author(s)
Takahashi M, Niwa K, Ishiyama S, Sugimoto K, Komiyama H, Yaginuma Y, Kojima Y, Goto M, Okuzawa A, Tomiki Y, Sakamoto
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Journal Title
J Med Case Rep
Volume: 8
Pages: 1-6
Related Report
Peer Reviewed / Open Access
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[Journal Article] Investigation of free cancer cells in peripheral blood using CEA mRNA expression in perioperative colorectal cancer patients.2013
Author(s)
Nagayasu K, Komiyama H, Ishiyama S, Ogura D, Takahashi R, Tashiro Y, Niwa K, Sugimoto K, Kojima Y, Goto M, Tomiki Y, Niwa S, Sakamoto K.
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Journal Title
Molecular and clinical oncology
Volume: 1
Issue: 4
Pages: 668-674
DOI
Related Report
Peer Reviewed
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[Presentation] Polymeric CTC を用いた大腸癌CTCの検出2016
Author(s)
呉 一眞, 細谷 理樹, 塚本 亮一, 伊藤 慎吾, 本庄 薫平, 岡澤 裕, 水越 幸輔, 宗像 慎也, 石山 隼, 杉本 起一, 神山 博彦, 小見山 博光, 高橋 玄, 柳沼 行宏, 小島 豊, 五藤 倫敏, 奥澤 淳司, 冨木 裕一, 坂本 一博, 大永 崇
Organizer
第116回日本外科学会外科定期学術集会
Place of Presentation
大阪
Year and Date
2016-04-14
Related Report
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[Presentation] Comparisons of long-term outcomes for locally advanced colon cancer between laparoscopic colectomy and open colectomy; propensity score analysis2015
Author(s)
Sugimoto K, Sakamoto K, Tomiki Y, Goto M, Kojima Y, Komiyama H, Takahashi M, Kamiyama H, Ishiyama S, Niwa K, Ito S, Kawai M, Takehara K, Tashiro T, Munakata S, Aoki J, Okazawa Yu O, Takahashi R, Mizukoshi K, Ro H, Ichikawa R, Kure K, Honjyo K, Tsukamoto R.
Organizer
23th International Congress of the EAES
Place of Presentation
Bucharest, Romania
Year and Date
2015-06-03
Related Report
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[Presentation] CHFR methylation is An Independent Prognostic Marker of Poor Prognosis in Gastric Cancer2015
Author(s)
Sugimoto K, Humbert A, Lu Z, Chen C, Rodgers K, Lee,B Griffin C, Sato K, Orita H, Ito T, Komiyama H, Kojima Y, Goto M, Tomiki Y, Sakamoto K, Brock M
Organizer
American Association for Cancer Research106th Annual Meeting
Place of Presentation
Pennsylvania,USA
Year and Date
2015-04-18
Related Report
Int'l Joint Research
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[Presentation] LAPAROSCOPIC ABDOMINOPERINEAL RESECTION FOR RECTAL CANCER2014
Author(s)
Kazuhiro Sakamoto, Ro Hishaho, Kure Kazumasa, Honjo Kumpei, Aoki Jun, Okazawa Yu, Takehara Takahashi Rina, Ishiyama Shun, Sugimoto Kiichi, Yaginuma Hiroyuki, Takahashi Makoto, Kojima Yutaka, Goto Michitoshi, Okuzawa Atsushi, Tomiki Yuichi
Organizer
The 14th World Congress of Endoscopic Surgery
Place of Presentation
Paris
Year and Date
2014-06-25 – 2014-06-28
Related Report
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