Ischemia Modified Albumin is a possible marker of long-term hypoxia in respiratory disease.

• Project/Area Number: 25460701
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Showa University
• Principal Investigator: Kimura Satoshi 昭和大学, 医学部, 教授 (30255765)
• Research Collaborator: Gugliucci Alejandro C カリフォルニア州トウロ大学, 教授
• Project Period (FY): 2013-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 慢性呼吸不全 / 低酸素血症 / 虚血変性アルブミン / 比色法 / 血中マーカー / 長期マーカー / 脳血管障害 / 在宅酸素療法 / 組織虚血 / 血液ガス / Paraoxonase 1 / 慢性閉塞性肺疾患 / IMA / PON1 / sRAGE

Outline of Final Research Achievements

Partial pressure of oxygen in arterial blood and oxygen saturation have been used as hypoxia markers. Since they represent only at the moment of measure, physicians cannot evaluate severity of hypoxia while patients are staying home.
Glyco-albumin represents degree of hyperglycemia in a recent week. With similar manner. Albumin is irreversibly altered to Ischemia-modified albumin (IMA) which can be assayed with colorimetric method. We found increased serum concentration of IMA in severe respiratory disease patients. With successful treatment, their IMA level decreased. Thus, we assume IMA could reflect ling-term hypoxia.

Academic Significance and Societal Importance of the Research Achievements

気管支喘息など慢性的な呼吸不全患者において、予期せぬ突然の容態急変はよく遭遇する現象である。自宅や外出中に起きた発作の重症度を反映する「長期低酸素血症のマーカー」はいまだ確立されておらず、外来患者に対し迅速かつ安価に測定できるマーカーが求められてきた。我々の検査法は、「比色法」という非常に簡単な原理で実施できるため、将来は自動分析機に搭載し緊急検査にも応用できる。今後は実際に多くの症例の検討を行い、慢性呼吸不全患者のQOL向上に貢献したい

Research Products

• [Int'l Joint Research] Touro University California/Professor Alejandro Gugliucci(米国)
• [Int'l Joint Research] Touro University California(米国)
• [Int'l Joint Research] Tuoro University California(米国)
• [Int'l Joint Research] Professor Alejandro C Gugliucci/Biochemistry Laboratory/Tuoro University California(米国)
• [Journal Article] Serum ischemia-modified albumin concentration may reflect long-term hypoxia in chronic respiratory disease: a pilot study. (2018)
  • Author(s): Kimura S, Yamaguchi H, Shikama Y, Tateno H, Kawaguchi M, Kotani K, Menini T, Gugliucci A.
  • Journal Title: Clin Chem Lab Med. Volume: 56(12) Issue: 12 Pages: e288-e290
  • DOI: 10.1515/cclm-2018-0150
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum Ischemia-Modified Albumin Concentration May Reflect Long-Term Hypoxia in Chronic Respiratory Disease: A Pilot Study. (2018)
  • Author(s): Satoshi Kimura et al.
  • Journal Title: Clinical Chemistry and Laboratory Medicine Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Paraoxonase 1 lactonase activity and distribution in the HDL subclasses in the cord blood. (2014)
  • Author(s): Gugliucci A, Numaguchi A, Caccavello R, Kimura S
  • Journal Title: Redox Report Volume: 19 (3) Issue: 3 Pages: 124-132
  • DOI: 10.1179/1351000213y.0000000081
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Small-dense low-density lipoproteins are the predominant apoB-100-containing lipoproteins in cord blood. (2014)
  • Author(s): Gugliucci A, Numaguchi M, Caccavello R, Kimura S
  • Journal Title: Clinical Biochemistry Volume: 47 Issue: 6 Pages: 475-477
  • DOI: 10.1016/j.clinbiochem.2013.12.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Circulating soluble RAGE increase after a cerebrovascular event. (2014)
  • Author(s): Menini T, Ikeda H, Kimura S, Gugliucci A
  • Journal Title: Clin Chem Lab Med Volume: 52 Issue: 1 Pages: 109-116
  • DOI: 10.1515/cclm-2012-0813
  • Peer Reviewed
• [Journal Article] Enzymatic assessment of paraoxinase 1 activity on HDL subclasses: A practical zymogram method to assess HDL function. (2013)
  • Author(s): Gucliucci A, Caccavello R, Kotani K, Sakane N, Kimura S
  • Journal Title: Clinica Chimica Acta Volume: 415 Pages: 162-168
  • DOI: 10.1016/j.cca.2012.10.044
  • Peer Reviewed
• [Presentation] Serum ischemia-modified albumin levels reflect long-term hypoxia in respiratory disease; a pilot study. (2017)
  • Author(s): Kimura S, et al.
  • Organizer: IFCC-EFLM EuroMedLab 2017
  • Place of Presentation: Athens, Greece
  • Year and Date: 2017-06-11
  • Int'l Joint Research
• [Presentation] SERUM ISCHEMIA-MODIFIED ALBUMIN LEVELS REFLECT LONG-TERM HYPOXIA IN RESPIRATORY DISEASE; A PILOT STUDY. (2017)
  • Author(s): Satoshi Kimura et al.
  • Organizer: IFCC-EFLM EuroMedLab 2017
  • Int'l Joint Research
• [Presentation] SERUM ISCHEMIA-MODIFIED ALBUMIN LEVELS INCREASE IN RESPIRATORY DISEASE PATIENTS WITH HYPOXIA IN RECENT WEEKS; A PILOT STUDY. (2017)
  • Author(s): Satoshi Kimura et al.
  • Organizer: IFCC Worldlab Durban 2017
  • Int'l Joint Research
• [Presentation] Does Serum Ischemia-Modified Albumin Concentration Reflect Long-Term Hypoxia in Chronic Respiratory Disease? (2017)
  • Author(s): Satoshi Kimura et al.
  • Organizer: The 29th World Congress of World Association of Pathology and Laboratory Medicine
  • Int'l Joint Research