| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
In this study, we identified a transcriptional start sites and its promoter structure of CD94, NKG2D and NCR2. The effects of IL-2 treatment for the Glycan-dependent cytotoxicity on NK cells was studied:
(1) Expression of NKG2A was decreased on KHYG cells-treated with IL-2. (2) The CD94-NKG2A complexes did not colocalized with GM1 at the cell membrane in KHYG cells-treated with IL-2.
This study suggests that the NKG2D signals was enhanced by the inhibition of signal transduction from NKG2A by glycan ligand in NK cells with IL-2, resulting that the glycan-dependent cytotoxicity was induced.
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