• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Diacetylspermine in urine, a tumor marker: studies on its clinical usefulness, metabolism, and simple and rapid determination

Research Project

Project/Area Number 25460714
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

HIRAMATSU Kyoko  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (80181189)

Co-Investigator(Kenkyū-buntansha) 川喜田 正夫  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 研究員 (00012740)
Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Keiichi  公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 客員研究員 (60443115)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsジアセチルスペルミン / 腫瘍マーカー / 尿検査 / 大腸癌 / 肺癌 / イムノクロマト / 癌の早期発見 / 癌のフォローアップ
Outline of Final Research Achievements

This study was conducted to establish N1,N12-diacetylspermine (DiAcSpm) as a useful tumor marker, and to develop a simple and rapid procedure for DiAcSpm determination. Our study revealed that DiAcSpm was increased in early cancer tissues, and that this increase is responsible for the increased excretion of DiAcSpm in the urine of patients with early colorectal cancer patients. Further study indicated that preoperative urinary DiAcSpm level was significantly related with the risk of early recurrence of completely resected colorectal cancer and non-small cell lung cancer patients. We also developed an
immunochromatographic device for simple and rapid determination of urinary DiAcSpm. The simplicity of the procedure is a definite merit in promoting wider use of urinary DiAcSpm testing, a non-invasive and sensitive measure for early cancers.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (33 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Open Access: 4 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results) Presentation (20 results) (of which Invited: 4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] 大腸癌治癒切除症例の早期再発リスク評価における尿中N1,N12-ジアセチルスペルミンと血清CEA併用の臨床的意義2017

    • Author(s)
      高橋慶一,平松恭子,山口達郎,松本寛,森谷俊介,川喜田正夫
    • Journal Title

      日本分子腫瘍マーカー研究会誌

      Volume: 32 Pages: 35-36

    • NAID

      130005466732

    • Related Report
      2016 Annual Research Report
    • Open Access
  • [Journal Article] Significant correlation between urinary N1, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer.2015

    • Author(s)
      Takahashi Y, Horio H, et al.
    • Journal Title

      BMC Cancer

      Volume: 15 Issue: 1 Pages: 65-65

    • DOI

      10.1186/s12885-015-1068-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma2015

    • Author(s)
      Saulnier Sholler GL, Gerner EW, Bergendahl G, MacArthur RB, VanderWerff A, Ashikaga T, Bond JP, Ferguson W, Roberts W, Wada RK, Eslin D, Kraveka JM, Kaplan J, Mitchell D, Parikh NS, Neville K, Sender L, Higgins T, Kawakita M, Hiramatsu K, Moriya S, Bachmann AS
    • Journal Title

      Plos One

      Volume: 10 Issue: 5 Pages: e0127246-e0127246

    • DOI

      10.1371/journal.pone.0127246

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Urinary N1, N12-diacetylspermine is a non-invasive marker for the diagnosis and prognosis of non-small cell lung cancer2015

    • Author(s)
      Takahashi Y, Sakaguchi K, Horio H, Hiramatsu K, Moriya S, Takahashi K, Kawakita M
    • Journal Title

      Brit. J. Cancer

      Volume: 115 Issue: 10 Pages: 1493-1501

    • DOI

      10.1038/bjc.2015.349

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Excretion of N1,N12-diacetylspermine in the urine of healthy individuals.2014

    • Author(s)
      Kyoko Hiramatsu, Kouji Sakaguchi, Nana Fujie, Fumie Saitoh, Emi Takahama Shun-suke Moriya, Kaori Iwasaki, Masayoshi Sakaguchi, Kei-ichi Takahashi and Masao Kawaikta
    • Journal Title

      Ann. Clin. Biochem.

      Volume: 未定 Issue: 6 Pages: 452-460

    • DOI

      10.1002/jcla.21709

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 1-(4-Aminobutyl)-2-iminoimidazolidin-4-one Aimed at Preparation of a Creatinine-Specific Antibody2014

    • Author(s)
      Shun-suke Moriya,Naoki Terayama,Kyoko Hiramatsu,Masao Kawakita,Tatsuya Kiryu,Takato Kawanishi,Eiko Yasui,Shinji Nagumo
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 62 Issue: 4 Pages: 350-353

    • DOI

      10.1248/cpb.c13-00960

    • NAID

      130003390789

    • ISSN
      0009-2363, 1347-5223
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excretion of N(1), N(12)-diacetylspermine in the urine of healthy individuals.2014

    • Author(s)
      Kyoko Hiramatsu, Kouji Sakaguchi, Nana Fujie, Fumie Saitoh, Emi Takahama,
    • Journal Title

      Ann Clin Biochem.

      Volume: 51 Issue: 4 Pages: 459-467

    • DOI

      10.1177/0004563213496978

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Irreversible Inactivators of Spermine Oxidase and <i>N</i><sup>1</sup>-Acetylpolyamine Oxidase2014

    • Author(s)
      Shun-suke Moriya, Toshiyuki Miura, Koichi Takao, Yoshiaki Sugita, Keijiro Samejima, Kyoko Hiramatsu, and Masao Kawakita
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 37 Issue: 3 Pages: 475-480

    • DOI

      10.1248/bpb.b13-00913

    • NAID

      130003390953

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increase of N1,N12-diacetylspermine in tissues from colorectal cancer and its liver metastasis.2013

    • Author(s)
      Go Kuwata, Kyoko Hiramatsu, Keijiro Samejima, Kaori Iwasaki, Kei-ichi Takahashi, Koichi Koizumi, Shin-ichiro Horiguchi, Shun-suke Moriya, Masaki Kobayashi, Masao Kawakita
    • Journal Title

      J. Cancer Res. Clin. Oncol.,

      Volume: 139 Issue: 6 Pages: 925-932

    • DOI

      10.1007/s00432-013-1405-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 婦人科悪性腫瘍におけるN1,N12-ジアセチルスペルミン測定の意義.2013

    • Author(s)
      八杉利治,平松 恭子, 岩崎香里,堀口慎一郎, 森谷 俊介,高橋 慶一,川喜田正夫
    • Journal Title

      日本分子腫瘍マーカー研究会誌

      Volume: 28 Pages: 39-40

    • NAID

      130005161399

    • Related Report
      2013 Research-status Report
  • [Presentation] 腫瘍組織のN1,N12-ジアセチルスペルミン量による子宮および卵巣腫瘍の良・悪性鑑別2017

    • Author(s)
      平松恭子,八杉利治,斎藤文江,高浜恵美,森谷俊介,遠藤典子,鮫島啓二郎,高橋慶一,川喜田正夫
    • Organizer
      日本ポリアミン学会第8回年会
    • Place of Presentation
      千葉工業大学津田沼キャンパス(千葉県・習志野市)
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 安定同位体標識ポリアミンを用いたラット再生肝内のポリアミン動態の解析2017

    • Author(s)
      森谷俊介,遠藤典子,鮫島啓二郎,平松恭子,川喜田正夫
    • Organizer
      日本ポリアミン学会第8回年会
    • Place of Presentation
      千葉工業大学津田沼キャンパス(千葉県・習志野市)
    • Year and Date
      2017-01-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸癌治癒切除症例の早期再発リスク評価における尿中N1,N12-ジアセチルスペルミンと血清CEA併用の臨床的意義2016

    • Author(s)
      高橋慶一,平松恭子,山口達郎,松本寛,森谷俊介,川喜田正夫
    • Organizer
      第36回日本分子腫瘍マーカー研究会
    • Place of Presentation
      パシフィコ横浜会議センター(神奈川県・横浜市)
    • Year and Date
      2016-10-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 子宮体癌、子宮頸癌および卵巣癌組織のN1,N12-ジアセチルスペルミン2016

    • Author(s)
      平松恭子,八杉利治,斎藤文江,高浜恵美,森谷俊介,遠藤典子,鮫島啓二郎,高橋慶一,川喜田正夫
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 安定同位体標識基質を用いたオルニチン脱炭酸酵素の活性測定2016

    • Author(s)
      森谷俊介,遠藤典子,鮫島啓二郎,平松恭子,川喜田正夫
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県・仙台市)
    • Year and Date
      2016-09-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸癌および非小細胞肺癌の手術前尿中ジアセチルスペルミン値と予後の関連2015

    • Author(s)
      平松恭子,高橋祐介,堀尾裕俊,高橋慶一,坂口幸治,森谷俊介,寺岡秀興,斉藤文江,高浜恵美,川喜田正夫
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 質量分析計と安定同位体標識基質を用いたポリアミン合成系酵素の活性測定法の検討2015

    • Author(s)
      森谷俊介,寺岡秀興,鮫島啓二郎,平松恭子,川喜田正夫
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] 手術前尿中N1,N12-ジアセチルスペルミンと非小細胞肺癌の予後2015

    • Author(s)
      平松恭子,高橋祐介,堀尾裕俊,高橋慶一,坂口幸治,斉藤文江,高岡恵美,森谷俊介,寺岡秀興,川喜田正夫
    • Organizer
      日本ポリアミン学会第7回年会
    • Place of Presentation
      京都工芸繊維大学 松ヶ崎キャンパス(京都市左京区)
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
  • [Presentation] 非小細胞肺癌における尿中ジアセチルスペルミン測定の臨床的意義2015

    • Author(s)
      掘尾裕俊,高橋祐介,坂口幸治,平松恭子,森谷俊介,寺岡秀興,川喜田正夫
    • Organizer
      第35回日本分子腫瘍マーカー研究会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 大腸癌の手術前尿中ジアセチルスペルミン値と予後の関連2015

    • Author(s)
      平松恭子,高橋慶一,斎藤文江,高浜恵美,森谷俊介,寺岡秀興,川喜田正夫
    • Organizer
      日本ポリアミン学会第6回年会
    • Place of Presentation
      東京海洋大学大学院(東京都 港区)
    • Year and Date
      2015-01-19 – 2015-01-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Urine N1N12-diacetylspermine (DiAcSpm) as a new cancer marker for colorectal cancer.2014

    • Author(s)
      Keiichi Takahashi, Kyoko Hiramatsu, Tatsuro Yamaguchi, Hiroshi Matsumoto, Daisuke Nakano, Yuujiro Nakayama, Shunsuke Moriya, Masao Kawakita
    • Organizer
      7th European Multidisciplinary Colorectal Cancer Congress (EMCCC 2014)
    • Place of Presentation
      Amsterdam, Netherlands
    • Year and Date
      2014-11-24 – 2014-11-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 非小細胞肺癌切除例の予後における尿中ジアセチルスペルミンの意義2014

    • Author(s)
      高橋祐介,堀尾裕俊,村上聡子,原田匡彦,平松恭子,川喜田正夫
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-11-14 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] Urinary Tumor marker N1,N12-diacetylspermine: clinical significance, determination, production and excretion.2014

    • Author(s)
      Masao Kawakita, Kyoko Hiramatsu, Shunsuke Moriya, Keiichi Takahashi
    • Organizer
      The 1st Innovation Forum of Advance Engineering and Education
    • Place of Presentation
      Kogakuin University (Tokyo Shinjyuku)
    • Year and Date
      2014-11-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 安定同位体標識基質を用いたポリアミン合成2014

    • Author(s)
      森谷俊介,寺岡秀興,鮫島啓二郞,平松恭子,川喜田正夫
    • Organizer
      第87回日本生化学会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 臨床病期IA期非小細胞肺癌における尿中ジアセチルスペルミンと病理学的浸潤性との関係2014

    • Author(s)
      高橋祐介, 村上聡子, 原田匡彦, 堀尾裕俊, 平松恭子, 川喜田正夫
    • Organizer
      第31回日本呼吸器外科学会総会
    • Place of Presentation
      ホテル日航東京(東京都港区)
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] N 1,N12-ジアセチルスペルミンとその臨床応用に向けた取り組み.2014

    • Author(s)
      川喜田正夫, 平松恭子,森谷俊介,鮫島啓二郎,高橋慶一
    • Organizer
      第5回ポリアミン学会年会
    • Place of Presentation
      銚子
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 健常者尿中N 1,N12-ジアセチルスペルミン2014

    • Author(s)
      平松恭子,斎藤文江,高浜恵美,藤江奈々,森谷俊介, 坂口幸治,高橋慶一,川喜田正夫
    • Organizer
      第5回ポリアミン学会年会
    • Place of Presentation
      銚子
    • Related Report
      2013 Research-status Report
  • [Presentation] 癌患者における尿および組織中のN 1,N12-ジアセチルスペルミンの増加.2013

    • Author(s)
      川喜田正夫,桑田 剛,八杉利治,堀口慎一郎,森谷俊介,鮫島啓二郞,三浦俊之,小泉浩一,高橋慶一,平松恭子
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] アセチルポリアミンオキシダーゼ、スペルミンオキシダーゼ阻害薬.2013

    • Author(s)
      森谷俊介,三浦俊之,高尾浩一, 鮫島啓二郞,平松恭子,川喜田正夫
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃癌および悪性リンパ腫の薬物療法における治療効果、経過観察としての尿中N 1,N12-ジアセチルスペルミン2013

    • Author(s)
      平松恭子, 下山 達, 斉藤文江, 高浜恵美, 岩崎香里, 森谷俊介,前田善治, 高橋慶一, 川喜田正夫
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Book] Polyamines A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism(Kusano,T., Suzuki,H.eds)2015

    • Author(s)
      Kawakita M, Hiramatsu K, Moriya S, Samejima K, Takahashi K,
    • Publisher
      Springer
    • Related Report
      2014 Research-status Report
  • [Remarks] 公益財団法人東京都医学総合研究所 在籍研究者の主な研究発表等の実績

    • URL

      http://www.igakuken.or.jp/research_search/staff.php?id=%F8%DC%12%FE%8A%BC9%9F

    • Related Report
      2014 Research-status Report
  • [Remarks] 公益財団法人東京都医学総合研究所 ゲノム医科学研究分野 分子医療プロジェクト

    • URL

      http://www.molmed.jp/projectcorner/cancer.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi