| Project/Area Number |
25460717
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | University of Toyama |
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Principal Investigator |
ANDOH Tsugunobu 富山大学, 大学院医学薬学研究部(薬学), 准教授 (50333498)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Takeshi 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (10452442)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 痒み / アトピー性皮膚炎 / SASPase / プロテアーゼ / indinavir / 神経活動 / 抗ヒスタミン薬 |
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| Outline of Final Research Achievements |
Aspartic protease SASPase in the skin of mice with atopy-like dermatitis (dermatitis mice) has been found using proteome analysis in our previous study. In this study, we examined whether SASPase was involved in itching in mice with atopic dermatitis. The expression of SASPase was increased in the skin of dermatitis mice, compared with healthy mice. An intradermal SASPase, but not heat-inactivated SASPase, elicited itch-related responses. SASPase was distributed in epidermis, especially granular layer and stratum spinosum. In the skin of dermatitis mice, the peripheral nerves were elongated into the epidermis. Interestingly, SASPase digested nerve repellent factor expressed in epidermis. These findings suggest that SASPase is one of itch mediators and also may play an important role on the elongation of peripheral sensory nerves.
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