| Project/Area Number |
25460720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kawasaki Medical School (2015-2016)
Okayama University (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
永坂 岳司 岡山大学, 大学病院, 講師 (30452569)
佐藤 健治 岡山大学, 医歯薬学総合研究科, 准教授 (70359884)
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| Research Collaborator |
KANZAKI Hirotaka 岡山大学病院, 薬剤部
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 慢性痛 / 遺伝子解析 / 難治性慢性痛 / 集学的診療 / 遺伝子検査 |
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| Outline of Final Research Achievements |
Pain that lasts for 3 months or more is called chronic pain, and clinical practice (multidisciplinary pain treatment: MPT) by multidisciplinary experts is considered to be effective for reducing chronic pain. Evaluation of pain for pain management is difficult. Currently, pain is evaluated using a self-recorded questionnaire, but the method lacks objectivity. We are interested in genetic information, especially blood microRNAs, as an indicator of pain. MPT was conducted for 6 months, and blood was collected before and after the treatment. We provided a comprehensive analysis of microRNAs in cases of pain improvement and invariant cases. Nine cases in which MPT was performed were used. For each questionnaire, we evaluated the strength of the pain, patient’s mental state, catastrophic thoughts of pain, quality of life, and physical function. We found that some microRNAs may be associated with effectiveness of MPT.
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