| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The present study investigated to reveal the astrocyte-neuron lactate shuttle (ANLS) in the neuropathic pain. Intrathecal (i.t.) treatment with L-lactate induced mechanical hyperalgesia. Moreover, inhibition of L-lacate release from astrocytes attenuated the mechanical hyperalgesia in neuropathic pain model of mice. Therefore, our study suggested that astrocytes are critical nervous cells in the development and/or maintenance of neuropathic pain through the L-lactate and physical contact with neurons. Neuropathic pain model showed increased phosphorylation of protein kinase C (PKC) that sensitize the nociceptive transmission in the spinal cord. This phosphorylation PKC might be mediated by the different mechanisms from the release of gliotransmitter.
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