Investigation of the mechanisms and curatives for chronic pain based on the classical glial cells' functions.
| Project/Area Number |
25460724
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Nagoya City University |
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Principal Investigator |
Ohsawa Masahiro 名古屋市立大学, 薬学研究科(研究院), 准教授 (80369173)
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| Co-Investigator(Kenkyū-buntansha) |
Yamamoto Shohei 川崎医科大学, 医学部, 助教 (90433226)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アストロサイト / 乳酸 / Rhoキナーゼ / プロテインキナーゼC / DREADD / 神経障害性疼痛 / 痛覚過敏 / 細胞内情報伝達系 / Protein kinase C / モノカルボン酸トランスポーター |
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| Outline of Final Research Achievements |
The present study investigated to reveal the astrocyte-neuron lactate shuttle (ANLS) in the neuropathic pain. Intrathecal (i.t.) treatment with L-lactate induced mechanical hyperalgesia. Moreover, inhibition of L-lacate release from astrocytes attenuated the mechanical hyperalgesia in neuropathic pain model of mice. Therefore, our study suggested that astrocytes are critical nervous cells in the development and/or maintenance of neuropathic pain through the L-lactate and physical contact with neurons. Neuropathic pain model showed increased phosphorylation of protein kinase C (PKC) that sensitize the nociceptive transmission in the spinal cord. This phosphorylation PKC might be mediated by the different mechanisms from the release of gliotransmitter.
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Report
(4 results)
Research Products
(21 results)
