Investigation for the histamine-related mechanism of neuropathic pain and development of its therapy
| Project/Area Number |
25460725
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | Tohoku Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Hirokazu 東北薬科大学, 薬学部, 准教授 (30360069)
WATANABE Chizuko 東北薬科大学, 薬学部, 講師 (90296020)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | ヒスタミン / 難治性疼痛 / 脊髄 / ポリアミン / NMDA受容体 / 掻痒 |
|---|
| Outline of Final Research Achievements |
On the state of neuropathic pain, histamine-evoked pain-sensation, which is mediated through the direct activation of polyamine-recognition site of NMDA receptor in spinal cord by histamine, is enhanced. On the other hand, the super-sensitivity of TRPV1 receptor on the planter skin of paw was revealed to induce the neuropathic pain. The results of this project suggest that the spinal polyamine-recognition site of NMDA receptor and TRPV1 receptor on the skin may be key targets to develop the new therapy for neuropathic pain.
|
Report
(4 results)
Research Products
(42 results)
