Trigeminal contribution to the neurogenic inflammation in the dura mater
| Project/Area Number |
25460726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Mamoru 慶應義塾大学, 医学部, 講師 (60286466)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 片頭痛 / 硬膜 / 神経原性炎症 / 三叉神経 / 翼口蓋神経節 / CGRP / 三叉神経節 / TRPV1 |
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| Outline of Final Research Achievements |
We explored the relationship between the trigeminal fibers distributing the facial region and the dura mater. This study revealed that some neurons in the trigeminal ganglion send nerve fibers to facial region and the dura mater. These results indicate that the trigeminal nociceptive stimulation in the facial region may cause the activation of the nerve fibers in the dura mater. According to these findings, we explored the effects of nociceptive stimulation to the facial trigeminal nerve, and observed the morphological change of the mast cells in the dura mater. We revealed that nociceptive stimulation to the facial trigeminal nerve cause the degradation of the mast cells in the dura mater. These data provide important clues regarding the pathophysiology of migraine.
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Report
(4 results)
Research Products
(9 results)
