| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We explored the relationship between the trigeminal fibers distributing the facial region and the dura mater. This study revealed that some neurons in the trigeminal ganglion send nerve fibers to facial region and the dura mater. These results indicate that the trigeminal nociceptive stimulation in the facial region may cause the activation of the nerve fibers in the dura mater. According to these findings, we explored the effects of nociceptive stimulation to the facial trigeminal nerve, and observed the morphological change of the mast cells in the dura mater. We revealed that nociceptive stimulation to the facial trigeminal nerve cause the degradation of the mast cells in the dura mater. These data provide important clues regarding the pathophysiology of migraine.
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