Elucidation of roles of spinal glial cells in intractable itch and development of antipruritic therapy

• Project/Area Number: 25460727
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Juntendo University
• Principal Investigator: Takamori Kenji 順天堂大学, 医学部, 教授 (40053144)
• Co-Investigator(Kenkyū-buntansha): Tominaga Mitsutoshi 順天堂大学, 医学研究科, 准教授 (50468592) ; Kamo Atsuko 順天堂大学, 医学研究科, 助教 (50614088)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 難治性かゆみ / ミクログリア / アトピー性皮膚炎 / 脊髄 / ミノサイクリン / 脊髄後角 / かゆみ / グリア細胞

Outline of Final Research Achievements

This study was performed to investigate role of spinal glial cells, especially microglia, in intractable itch of atopic dermatitis (AD) using NC/Nga mouse, an AD model. Intrathecal injection of minocycline (an inhibitor of microglia) suppressed scratching behavior and improved the dermatitis scores through inhibition of increase of spinal microglia. Thus, this finding suggests that spinal microglial cell is one of antipruritic targets in AD.

Research Products

• [Journal Article] Intrathecal minocycline suppresses itch-related behavior and improves dermatitis in atopic dermatitis model mouse. (2016)
  • Author(s): Torigoe K, Tominaga M, Ko KC, Takahashi N, Matsuda H, Hayashi R, Ogawa H, Takamori K.
  • Journal Title: J Invest Dermatol Volume: 136 Issue: 4 Pages: 879-881
  • DOI: 10.1016/j.jid.2015.12.037
  • Peer Reviewed
• [Journal Article] Neurotropin suppresses itch-related behavior in NC/Nga mice with atopic dermatitis-like symptoms. (2016)
  • Author(s): Kamo A, Tominaga M, Matsuda H, Kina K, Kamata Y, Umehara Y, Ogawa H, Takamori K.
  • Journal Title: J Dermatol Sci Volume: 81 Issue: 3 Pages: 212-215
  • DOI: 10.1016/j.jdermsci.2015.11.014
  • Peer Reviewed
• [Journal Article] Possible anti-pruritic mechanisms of cyclosporine A in atopic dermatitis. (2016)
  • Author(s): Ko KC, Tominaga M, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K.
  • Journal Title: Acta Derm Venereol Volume: 未定 Issue: 5 Pages: 624-629
  • DOI: 10.2340/00015555-2318
  • Peer Reviewed / Open Access
• [Journal Article] Definition of Sensitive Skin: an Expert Position Paper from the Special Interest Group on Sensitive Skin of the International Forum for the Study of Itch. (2016)
  • Author(s): Misery L, Stander S, Szepietowski JC, Reich A, Wallengren J, Evers AW, Takamori K, Brenaut E, Gall-Ianotto CL, Fluhr J, Berardesca E, Weisshaar E.
  • Journal Title: Acta Derm Venereol Volume: 未定 Issue: 1 Pages: 4-6
  • DOI: 10.2340/00015555-2397
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Skin pH is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model. (2016)
  • Author(s): Jang H, Matsuda A, Jung K, Karasawa K, Matsuda K, Oida K, Ishizaka S, Ahn G, Amagai Y, Moon C, Kim SH, Arkwright PD, Takamori K, Matsuda H, Tanaka A.
  • Journal Title: J. Invest. Dermatol. Volume: 136 Issue: 1 Pages: 127-136
  • DOI: 10.1038/jid.2015.363
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Tumour-promoting activity of polycyclic aromatic hydrocarbons and their oxygenated or nitrated derivatives. (2016)
  • Author(s): Misaki K, Takamura-Enya T, Ogawa H, Takamori K, Yanagida M.
  • Journal Title: Mutagenesis Volume: 2 Issue: 2 Pages: 205-213
  • DOI: 10.1093/mutage/gev076
  • Peer Reviewed
• [Journal Article] TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells (2016)
  • Author(s): Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 23616-23616
  • DOI: 10.1038/srep23616
  • Peer Reviewed / Open Access
• [Journal Article] Simple quantitation for potential serum disease biomarker peptides, primarily identified by a peptidomics approach in the serum with hypertensive disorders of pregnancy. (2016)
  • Author(s): Hamamura K, Nonaka D, Ishikawa H, Banzai M, Yanagida M, Nojima M, Yoshida K, Lee LJ, Tanaka K, Takamori K, Takeda S, Araki Y
  • Journal Title: Ann Clin Biochem Volume: 53 Issue: 1 Pages: 85-96
  • DOI: 10.1177/0004563215583697
  • Peer Reviewed
• [Journal Article] Cathelicidin LL-37 induces semaphorin 3A production in human epidermal keratinocytes: implications for possible application to pruritus. (2015)
  • Author(s): Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K.
  • Journal Title: J Invest Dermatol Volume: 135 Issue: 11 Pages: 2887-2890
  • DOI: 10.1038/jid.2015.243
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Retinoid-related orphan receptor alpha is involved in induction of semaphorin 3A expression in normal human epidermal keratinocytes (2015)
  • Author(s): Yayoi Kamata, Mitsutoshi Tominaga, Azumi Sakaguchi, Yoshie Umehara, Osamu Negi, Hideoki Ogawa, Kenji Takamori
  • Journal Title: J Dermatol Sci Volume: 印刷中 Issue: 1 Pages: 84-86
  • DOI: 10.1016/j.jdermsci.2015.03.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Topical application of Tenshino-softgelTM reduces epidermal nerve fiber density in a chronic dry skin model mouse. (2015)
  • Author(s): Noguchi A, Tominaga M, Ko KC, Matsuda H, Suga Y, Ogawa H, Takamori K.
  • Journal Title: Journal of Cosmetics, Dermatological Sciences and Applications Volume: 5 Issue: 04 Pages: 254-261
  • DOI: 10.4236/jcdsa.2015.54031
  • Peer Reviewed / Open Access
• [Journal Article] Tinea Faciei Caused by Trichophyton mentagrophytes (Molecular Type Arthroderma benhamiae) Mimics Impetigo : A Case Report and Literature Review of Cases in Japan. (2015)
  • Author(s): Kimura U, Yokoyama K, Hiruma M, Kano R, Takamori K, Suga Y.
  • Journal Title: Med Mycol J Volume: 56 Issue: 1 Pages: 1-5
  • DOI: 10.3314/mmj.56.e1
  • NAID: 130005064300
  • Peer Reviewed
• [Journal Article] Chemical characterization of N-linked oligosaccharide as the antigen epitope recognized by an anti-sperm auto-monoclonal antibody, Ts4. (2015)
  • Author(s): Yoshitake H, Hashii N, Kawasaki N, Endo S, Takamori K, Hasegawa A, Fujiwara H, Araki Y.
  • Journal Title: PLoS One Volume: 10 Issue: 7 Pages: e0133784-e0133784
  • DOI: 10.1371/journal.pone.0133784
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis. (2015)
  • Author(s): Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.
  • Journal Title: Autoimmunity Volume: 49(2) Issue: 2 Pages: 109-14
  • DOI: 10.3109/08916934.2015.1113405
  • Peer Reviewed / Open Access
• [Journal Article] Properties and functions of lactosylceramide from mouse neutrophils (2015)
  • Author(s): Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K
  • Journal Title: Glycobiology Volume: 25 Issue: 6 Pages: 655-668
  • DOI: 10.1093/glycob/cwv008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Properties and functions of lactosylceramide from mouse neutrophils (2015)
  • Author(s): Iwabuchi K, Masuda H, Kaga N, Nakayama H, Matsumoto R, Iwahara C, Yoshizaki F, Tamaki Y, Kobayashi T, Hayakawa T, Ishii K, Yanagida M, Ogawa H, Takamori K
  • Journal Title: Glycobiology Volume: in press
  • Peer Reviewed
• [Journal Article] Mechanisms of itch in atopic dermatitis (2015)
  • Author(s): Tominaga M, Kamata Y, Umehara Y, Ko KC, Takamori K
  • Journal Title: J Environ Dermatol Cutan Allergol Volume: 9 Pages: 1-11
  • NAID: 10012524941
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] かゆみと皮膚-セマフォリン他について- (2015)
  • Author(s): 冨永光俊、高森建二
  • Journal Title: 日皮会誌「皮膚科セミナリウム」 Volume: 125 Pages: 395-402
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] かゆみのメカニズム (2015)
  • Author(s): 冨永光俊、加茂敦子、鎌田弥生、高森建二
  • Journal Title: Mebio Volume: 32 Pages: 29-37
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The excimer lamp induces cutaneous nerve degeneration and reduces scratching in a dry-skin mouse model. (2014)
  • Author(s): Atsuko Kamo, Mitsutoshi Tominaga, Yayoi Kamata, Kazuyuki Kaneda, Kyi Chan Ko, Hironori Matsuda, Utako Kimura, Hideoki Ogawa, Kenji Takamori
  • Journal Title: J Invest Dermatol Volume: 134 Issue: 12 Pages: 2977-2984
  • DOI: 10.1038/jid.2014.256
  • Peer Reviewed
• [Journal Article] Role of spinal bombesin-responsive neurons in non-histaminergic itch (2014)
  • Author(s): Akiyama T, Tominaga M, Takamori K, Iodi Carstens M, Carstens E
  • Journal Title: J Neurophysiol Volume: 112 Issue: 9 Pages: 2283-9
  • DOI: 10.1152/jn.00409.2014
  • Peer Reviewed
• [Journal Article] Importance of the tryptophan nitration of carbonic anhydrase III for the morbidity of atopic dermatitis (2014)
  • Author(s): Hiroaki Kawasaki, Mitsutoshi Tominaga, Ayako Shigenaga, Atsuko Kamo, Yayoi Kamata, Kyoichi Iizumi, Utako Kimura, Hideoki Ogawa, Kenji Takamori, Fumiyuki Yamakura
  • Journal Title: Free Radic Biol Med Volume: 73 Pages: 75-83
  • DOI: 10.1016/j.freeradbiomed.2014.04.034
  • Peer Reviewed
• [Journal Article] Mating type gene for isolates of Trichophyton mentagrophytes from guinea pigs (2014)
  • Author(s): Hiruma J, Kano R, Kimura U, Takamori K, Suga Y, Hiruma M, Hasegawa A, Tsuboi R
  • Journal Title: J Dermatol Volume: 41 Pages: 743-5
  • Peer Reviewed
• [Journal Article] Antibody against chromatin assembly factor-1 is a novel autoantibody specifically recognized in systemic lupus erythematosus (2014)
  • Author(s): Doe K, Nozawa K, Hiruma K, Yamada Y, Matsuki Y, Nakano S, Ogasawara M, Nakano H, Ikeda T, Ikegami T, Fujishiro M, Kawasaki M, Ikeda K, Amano H, Morimoto S, Ogawa H, Takamori K, Sekigawa I, Takasaki Y
  • Journal Title: Lupus Volume: 23 Issue: 10 Pages: 1031-41
  • DOI: 10.1177/0961203314536245
  • Peer Reviewed
• [Journal Article] Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis (2014)
  • Author(s): Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y
  • Journal Title: Autoimmunity Volume: 29 Pages: 1-8
  • Peer Reviewed
• [Journal Article] 皮膚掻痒 (2014)
  • Author(s): 髙森建二
  • Journal Title: medicine～内科医のための皮疹の診かたのロジック～ Volume: 51 Pages: 842-847
• [Journal Article] 透析患者の皮疹 (2014)
  • Author(s): 髙森建二
  • Journal Title: medicine～内科医のための皮疹の診かたのロジック～ Volume: 51 Pages: 880-884
• [Journal Article] 皮膚科的合併症 (2014)
  • Author(s): 髙森建二
  • Journal Title: 腎と透析 Volume: 76 Pages: 388-390
• [Journal Article] Itch and nerve fibers with special reference to atopic dermatitis: Therapeutic implications. (2014)
  • Author(s): Tominaga M, Takamori K
  • Journal Title: J Dermatol Volume: 41 Issue: 3 Pages: 205-212
  • DOI: 10.1111/1346-8138.12317
  • Peer Reviewed
• [Journal Article] Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate (2014)
  • Author(s): Oizumi A, Nakayama H, Okino N, Iwahara C, Kina K, Matsumoto R, Ogawa H, Takamori K, Ito M, Suga Y, Iwabuchi K.
  • Journal Title: PLoS One. Volume: 9(2) Issue: 2 Pages: 89402-89402
  • DOI: 10.1371/journal.pone.0089402
  • Peer Reviewed / Open Access
• [Journal Article] Long-pulsed 1064-nm neodymium:yttrium-aluminum-garnet laser treatment for refractory warts on hands and feet. (2014)
  • Author(s): Kimura U, Takeuchi K, Kinoshita A, Takamori K, Suga Y
  • Journal Title: J Dermatol Volume: 41 Issue: 3 Pages: 252-257
  • DOI: 10.1111/1346-8138.12411
  • Peer Reviewed
• [Journal Article] Roles of glutamate, substance P, and gastrin-releasing peptide as spinal neurotransmitters of histaminergic and nonhistaminergic itch. (2014)
  • Author(s): Akiyama T, Tominaga M, Takamori K, Carstens MI, Carstens E
  • Journal Title: Pain Volume: 155 Issue: 1 Pages: 80-92
  • DOI: 10.1016/j.pain.2013.09.011
  • Peer Reviewed
• [Journal Article] Histamine H(4) receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model. (2014)
  • Author(s): Kamo A, Negi O, Tengara S, Kamata Y, Noguchi A, Ogawa H, Tominaga M, Takamori K
  • Journal Title: J Invest Dermatol Volume: 134 Issue: 2 Pages: 546-548
  • DOI: 10.1038/jid.2013.351
  • Peer Reviewed
• [Journal Article] 加齢と皮膚の生理機能（バリア機能を中心に） (2014)
  • Author(s): 冨永光俊、鎌田弥生、加茂敦子、高森建二
  • Journal Title: アレルギー・免疫 Volume: 21
• [Journal Article] 冬に多い肌トラブルを解消するポイントは乾燥から肌を守ること (2014)
  • Author(s): 髙森建二
  • Journal Title: 鉄道弘済会健康保険組合 保険だより Volume: 186 Pages: 14-15
• [Journal Article] 光線療法 (2014)
  • Author(s): 加茂敦子，髙森建二
  • Journal Title: Derma Volume: 2 Pages: 35-40
• [Journal Article] 透析患者の皮膚瘙痒症治療の決め手―難治なかゆみを和らげる解決法は？ (2014)
  • Author(s): 髙森建二
  • Journal Title: 苦手な外来皮膚疾患100の解決法～そのとき達人はどのように苦手皮膚疾患を克服したか？ Volume: 20 Pages: 68-69
• [Journal Article] Serum proteome analysis in patients with rheumatoid arthritis receiving therapy with tocilizumab: an anti-interleukin-6 receptor antibody. (2013)
  • Author(s): Yanagida M, Kawasaki M, Fujishiro M, Miura M, Ikeda K, Nozawa K, Kaneko H, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Sekigawa I
  • Journal Title: Biomed Res Int Volume: 2013 Pages: 607137-607137
  • DOI: 10.1155/2013/607137
  • Peer Reviewed
• [Journal Article] Overexpression of TEX101, a potential novel cancer marker, in head and neck squamous cell carcinoma. (2013)
  • Author(s): Yoshitake H., Yokoi H., Ishikawa H., Maruyama M., Endo S., Nojima M., Yoshida K., Yoshikawa H., Suzuki F., Takamori K., Fujiwara H., Araki Y.
  • Journal Title: Cancer Biomark Volume: 12 Issue: 10 Pages: 141-148
  • DOI: 10.1111/jog.12140
  • Peer Reviewed
• [Journal Article] An update on peripheral mechanisms and treatments of itch. (2013)
  • Author(s): Tominaga M, Takamori K
  • Journal Title: Biol Pharm Bull Volume: 36 Pages: 1241-1247
  • NAID: 130003361499
  • Peer Reviewed
• [Journal Article] A novel ATP2C1 early truncation mutation suggests haploinsufficiency as a pathogenic mechanism in a patient with Hailey-Hailey disease. (2013)
  • Author(s): Shibata A, Sugiura K, Kimura U, Takamori K, Akiyama M.
  • Journal Title: Acta Dermato-Venereol Volume: 93 Issue: 6 Pages: 719-720
  • DOI: 10.2340/00015555-1551
  • Peer Reviewed
• [Journal Article] GSL-enriched membrane microdomains in innate immune responses. (2013)
  • Author(s): Nakayama H, Ogawa H, Takamori K, Iwabuchi K.
  • Journal Title: Arch Immunol Ther Exp (Warsz). Volume: 61 Issue: 3 Pages: 217-28
  • DOI: 10.1007/s00005-013-0221-6
  • Peer Reviewed
• [Journal Article] Inhibition of connective tissue growth factor ameliorates rheumatoid arthritis in a murine model. (2013)
  • Author(s): Nozawa K, Fujishiro M, Kawasaki M, Yamaguchi A, Ikeda K, Morimoto S, Iwabuchi K, Yanagida M, Ichinose S, Morioka M, Ogawa H, Takamori K, Takasaki Y, Sekigawa I.
  • Journal Title: Arthritis Rheum. Volume: 65 Issue: 6 Pages: 1477-86
  • DOI: 10.1002/art.37902
  • Peer Reviewed
• [Journal Article] Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated dry-skin mouse model. (2013)
  • Author(s): Kamo A, Tominaga M, Taneda K, Ogawa H, Takamori K
  • Journal Title: Clin Exp Dermatol Volume: 38 Issue: 6 Pages: 665-668
  • DOI: 10.1111/ced.12100
  • Peer Reviewed
• [Journal Article] バリア機能と痒み (2013)
  • Author(s): 冨永光俊、高森建二
  • Journal Title: アレルギーの臨床 Volume: 33 Pages: 39-43
• [Journal Article] アトピー性皮膚炎のかゆみのメカニズムと新たなる治療戦略 (2013)
  • Author(s): 高森建二、冨永光俊
  • Journal Title: 臨床免疫・アレルギー科 Volume: 59 Pages: 191-197
• [Journal Article] 老人性乾皮症の痒み発生機序の解明と治療法開発 (2013)
  • Author(s): 冨永光俊、加茂敦子、髙森建二
  • Journal Title: 加齢皮膚医学セミナー Volume: 8 Pages: 23-28
• [Journal Article] 全身性皮膚そう;痒症 (2013)
  • Author(s): 髙森建二
  • Journal Title: JIM Volume: 23 Pages: 132-134
• [Journal Article] 単純型先天性表皮水疱症の２例の臨床経験 (2013)
  • Author(s): 大泉亜美，春名邦隆，寒竹正人，大日方薫，髙森建二，須賀康
  • Journal Title: 日本小児皮膚科学会雑誌 Volume: 32 Pages: 35-40
  • Peer Reviewed
• [Journal Article] STIとかゆみ (2013)
  • Author(s): 髙森建二
  • Journal Title: 日本性感染症学会誌 Volume: 24 Pages: 28-34
• [Journal Article] 順天堂大学浦安病院を受診した新規HIV感染者における皮膚症状の検討 (2013)
  • Author(s): 木下綾子，髙森建二，須賀康
  • Journal Title: 日本性感染症学会誌 Volume: 24 Pages: 140-147
• [Journal Article] 中高年のかゆみを招く乾燥肌は体の老化現象で肌の神経が過敏になり刺激に反応 (2013)
  • Author(s): 髙森建二
  • Journal Title: 健康365 Volume: 7 Pages: 26-27
• [Journal Article] 乾皮症になる前に (2013)
  • Author(s): 髙森建二
  • Journal Title: Slowage Volume: 10 Pages: 56-56
• [Journal Article] 血漿交換，ステロイドパルス，IVIG療法で加療した中毒性表皮壊死症 (2013)
  • Author(s): 野口篤，鈴木明子，竹内かおり，種田研一，春名邦隆，髙森建二，山田裕道，須賀康
  • Journal Title: 日本アフェレシス学会雑誌 Volume: 32 Pages: 93-93
• [Journal Article] 爪白癬に対するロングパルスNd：YAGレーザー治療 (2013)
  • Author(s): 木村有太子，武内かおり，木下綾子，髙森建二，比留間政太郎，須賀康
  • Journal Title: 日本美容皮膚科学会雑誌 Volume: 23 Pages: 280-288
• [Journal Article] かゆみとスキンケア (2013)
  • Author(s): 根木 治、冨永光俊、高森建二
  • Journal Title: Monthly Book Derma Volume: 210 Pages: 23-30
• [Presentation] Itching in atopic dermatitis: what’s new. (2016)
  • Author(s): Takamori K.
  • Organizer: American Academy of Dermatology (AAD) 47th Annual Meeting
  • Place of Presentation: Washington Convention Center (Washington D.C.)
  • Year and Date: 2016-03-04
  • Int'l Joint Research / Invited
• [Presentation] Electrophysiological characterization of BNP- and GRP-responsive dorsal horn neurons in spinal itch transmission. (2015)
  • Author(s): Tominaga M, Kusube F, Kawasaki H, Yamakura F, Naito H, Ogawa H, Tomooka Y, Takamori K
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2015-12-11
• [Presentation] Inhibitory factors in semaphorin 3A expression of human epidermal keratinocytes. (2015)
  • Author(s): Kamata Y, Umehara Y, Tominaga M, Negi O, Ogawa H, Takamori K.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2015-12-11
• [Presentation] Effects of antimicrobial peptides on expression of axon guidance molecules in normal human epidermal keratinocytes. (2015)
  • Author(s): Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2015-12-11
• [Presentation] Host defense protein S100A7/psoriasin regulates pores in the epidermis: aquaporins and tight junctions. (2015)
  • Author(s): Hattori F, Ikeda S, Okumura K, Tominaga M, Takamori K, Ogawa H, Okamoto K, Niyonsaba F.
  • Organizer: 第40回日本研究皮膚科学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2015-12-11
• [Presentation] ヒト表皮角化細胞を用いたセマフォリン3A遺伝子の近位プロモーター領域の解析. (2015)
  • Author(s): 鎌田弥生、冨永光俊、梅原芳恵、高森建二.
  • Organizer: 第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 2015-12-01
• [Presentation] ヒトiPS細胞からのかゆみ末梢神経誘導法の開発. (2015)
  • Author(s): 梅原芳恵、冨永光俊、松田浩則、鎌田弥生、髙森建二.
  • Organizer: 第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸)
  • Year and Date: 2015-12-01
• [Presentation] H1-ヒスタミン受容体拮抗薬による軸索ガイダンス分子の発現調節作用. (2015)
  • Author(s): 鎌田弥生、坂口安澄、梅原芳恵、冨永光俊、小川秀興、高森建二.
  • Organizer: 第45回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 島根県民会館(島根)
  • Year and Date: 2015-11-20
• [Presentation] 抗菌ペプチドLL-37は培養正常ヒト表皮角化細胞における神経反発因子semaphorin 3Aの発現を促進する. (2015)
  • Author(s): 梅原芳恵、鎌田弥生、冨永光俊、Francois Niyonsaba、小川秀興、高森建二.
  • Organizer: 第45回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 島根県民会館(島根)
  • Year and Date: 2015-11-20
• [Presentation] Intrathecal minocycline attenuates itch in atopic dermatitis mouse model. (2015)
  • Author(s): Torigoe K, Tominaga M, Takamori K.
  • Organizer: 8th World Congress on Itch
  • Place of Presentation: Nara Prefecture New Public Hall (Nara)
  • Year and Date: 2015-09-27
  • Int'l Joint Research
• [Presentation] Correlation of plasma granzyme B levels with pruritus of atopic dermatitis. (2015)
  • Author(s): Kamata Y, Kimura U, Matsuda H, Tengara S, Tominaga M, Ogawa H, Takamori K.
  • Organizer: 8th World Congress on Itch
  • Place of Presentation: Nara Prefecture New Public Hall (Nara)
  • Year and Date: 2015-09-27
  • Int'l Joint Research
• [Presentation] The effects of cathelicidin LL-37 on semaphorin 3A expression in normal human epidermal keratinocytes. (2015)
  • Author(s): Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K.
  • Organizer: 8th World Congress on Itch
  • Place of Presentation: Nara Prefecture New Public Hall (Nara)
  • Year and Date: 2015-09-27
  • Int'l Joint Research
• [Presentation] Pleiotropic action of cyclosporine on pruritus of atopic dermatitis. (2015)
  • Author(s): Tominaga M, Ko KC, Kamata Y, Umehara Y, Matsuda H, Takahashi N, Kina K, Ogawa M, Ogawa H, Takamori K.
  • Organizer: 8th World Congress on Itch
  • Place of Presentation: Nara Prefecture New Public Hall (Nara)
  • Year and Date: 2015-09-27
  • Int'l Joint Research
• [Presentation] 血漿グランザイム濃度とアトピー性皮膚炎の重症度の相関解析. (2015)
  • Author(s): 鎌田弥生、木村有太子、松田浩則、Suhandy Tengara、加茂 敦子、冨永光俊、高森建二.
  • Organizer: 第20回日本病態プロテアーゼ学会
  • Place of Presentation: ANAクラウンプラザホテルグランコート名古屋（名古屋）
  • Year and Date: 2015-08-21
• [Presentation] Antipruritic mechanisms of cyclosporine A in atopic dermatitis (2015)
  • Author(s): Takamori K
  • Organizer: 16th congress ESDaP
  • Place of Presentation: Saint-Petersburg, Russia
  • Year and Date: 2015-06-25 – 2015-06-27
  • Invited
• [Presentation] Epidermal nerve fibers in atopic dermatitis-updates (2015)
  • Author(s): Takamori K, Tominaga M
  • Organizer: 23rd World Congress of Dermatology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2015-06-08 – 2015-06-13
  • Invited
• [Presentation] Effects of H1-antihistamines on expression of axon guidance molecules in normal human epidermal keratinocytes (2015)
  • Author(s): Kamata Y, Sakaguchi A, Umehara Y, Tominaga M, Ogawa H, Takamori K
  • Organizer: 2015 SOCIETY FOR INVESTIGATIVE DERMATOLOGY (SID) annual meeting
  • Place of Presentation: Atlanta, Georgia, USA
  • Year and Date: 2015-05-06 – 2015-05-09
• [Presentation] The antimicrobial peptide cathelicidin LL-37 induces semaphorin 3A production in normal human epidermal keratinocytes (2015)
  • Author(s): Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K
  • Organizer: 2015 SOCIETY FOR INVESTIGATIVE DERMATOLOGY (SID) annual meeting
  • Place of Presentation: Atlanta, Georgia, USA
  • Year and Date: 2015-05-06 – 2015-05-09
• [Presentation] The antimicrobial peptide cathelicidin LL-37 induces semaphorin 3A production in normal human epidermal keratinocytes. (2015)
  • Author(s): Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Ogawa H, Takamori K.
  • Organizer: 2015 SOCIETY FOR INVESTIGATIVE DERMATOLOGY (SID) annual meeting
  • Place of Presentation: HILTON Atlanta (Georgia, USA)
  • Year and Date: 2015-05-06
  • Int'l Joint Research
• [Presentation] Effects of H1-antihistamines on expression of axon guidance molecules in normal human epidermal keratinocytes. (2015)
  • Author(s): Kamata Y, Sakaguchi A, Umehara Y, Tominaga M, Ogawa H, Takamori K.
  • Organizer: 2015 SOCIETY FOR INVESTIGATIVE DERMATOLOGY (SID) annual meeting
  • Place of Presentation: HILTON Atlanta (Georgia, USA)
  • Year and Date: 2015-05-06
  • Int'l Joint Research
• [Presentation] Analysis of spinal neurotransmitters in histaminergic and non-histaminergic itch (2014)
  • Author(s): Tominaga M, Akiyama T, Carstens MI, Carstens E, Takamori K
  • Organizer: 第39回日本研究皮膚科学会
  • Place of Presentation: ホテル阪急エキスポパーク（大阪府吹田市）
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] Roles of granzyame A in pathology of patients with atopic dermatitis (2014)
  • Author(s): Kamata Y, Kimura U, Matsuda H, Tengara S, Iizumi K, Tominaga M, Takamori K
  • Organizer: 第39回日本研究皮膚科学会
  • Place of Presentation: ホテル阪急エキスポパーク（大阪府吹田市）
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] Role of cyclosporine A in inhibitory mechanism of pruritus in atopic dermatitis (2014)
  • Author(s): Ko KC, Tominaga M, Kamata Y, Umehara Y, Takamori K
  • Organizer: 第39回日本研究皮膚科学会
  • Place of Presentation: ホテル阪急エキスポパーク（大阪府吹田市）
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] Effects of antimicrobial peptides on semaphorin 3A expression in normal human epidermal keratinocytes (2014)
  • Author(s): Umehara Y, Kamata Y, Tominaga M, Niyonsaba F, Takamori K
  • Organizer: 第39回日本研究皮膚科学会
  • Place of Presentation: ホテル阪急エキスポパーク（大阪府吹田市）
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] Irradiation of excimer lamp induces intraepidermal nerve degeneration and inhibits itch-related behavior in a dry-skin mouse model (2014)
  • Author(s): Kamo A, Tominaga M, Kamata Y, Kaneda K, Ko KC, Matsuda H, Kimura U, Takamori K
  • Organizer: 第39回日本研究皮膚科学会
  • Place of Presentation: ホテル阪急エキスポパーク（大阪府吹田市）
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] Spinal antinociceptive effect of gastrin releasing peptide (GRP) via GABAergic inhibitory interneurons expressing the GRP receptor (GRPR) (2014)
  • Author(s): Akiyama T, Tominaga M, Davoodi A, Nagamine M, Takamori K, Carstens MI, Carstens E
  • Organizer: Neuroscience 2014
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2014-11-15 – 2014-11-19
  • Invited
• [Presentation] 表皮内神経線維に対する紫外線療法エキシマランプ照射の影響-難治性痒み治療としての有用性の検討- (2014)
  • Author(s): 加茂敦子、冨永光俊、高森建二
  • Organizer: 第13回コ・メディカル形態機能学会
  • Place of Presentation: 北九州国際会議場（北九州市小倉北区）
  • Year and Date: 2014-11-08
• [Presentation] Antimicrobial peptide LL-37 induces semaphorin 3A in normal human epidermal keratinocytes. (2014)
  • Author(s): Umehara Y, Kamata Y, Tominnaga M, Niyonsaba F, Takamori K
  • Organizer: 第24回国際かゆみシンポジウム
  • Place of Presentation: ベルサール神保町（東京千代田区）
  • Year and Date: 2014-10-18
• [Presentation] Antipruritic mechanisms of cyclosporine A in atopic dermatitis mouse (2014)
  • Author(s): Ko KC, Tominaga M, Kamata Y, Umehara Y, Takamori K
  • Organizer: 第24回国際かゆみシンポジウム
  • Place of Presentation: ベルサール神保町（東京千代田区）
  • Year and Date: 2014-10-18
• [Presentation] アトピー性皮膚炎の難治性痒み発現におけるグランザイムAの役割 (2014)
  • Author(s): 鎌田弥生、木村有太子、Suhandy Tengara、加茂 敦子、冨永光俊、高森建二
  • Organizer: 第19回日本病態プロテアーゼ学会
  • Place of Presentation: 千里ライフサイエンスセンター（大阪府豊中市）
  • Year and Date: 2014-08-08 – 2014-08-09
• [Presentation] The retinoid-related orphan receptor RORpromote semaphorin 3A expression in human keratinocytes (2014)
  • Author(s): Kamata Y, Tominaga M, Umehara Y, Takamori K
  • Organizer: 2014 SOCIETY FOR INVESTIGATIVE DERMATOLOGY (SID) annual meeting
  • Place of Presentation: Albuquerque, New Mexico, USA
  • Year and Date: 2014-05-07 – 2014-05-10
  • Invited
• [Presentation] Recent topics of itch in atopic dermatitis (2014)
  • Author(s): Takamori K
  • Organizer: 12th BADV congress
  • Place of Presentation: Riga, Latvia
  • Invited
• [Presentation] Histamine H4 receptor antagonists exhibit insufficient anti-pruritic and anti-inflammatory effects on mite extract ointment-induced mouse model of atopic dermatitis (2013)
  • Author(s): Tominaga M, Kamo A, Negi O, Tengara S, Kamata Y, Noguchi A, Takamori K
  • Organizer: International Investigative Dermatology (IID) 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] Molecular mechanisms of Sema3A gene regulation in human epidermal keratinocytes (2013)
  • Author(s): Kamata Y, Tominaga M, Kamo A, Takamori K
  • Organizer: International Investigative Dermatology (IID) 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] Excimer lamp irradiation induces reduction of intraepidermal nerve fibre: implications for possible application to intractable pruritus (2013)
  • Author(s): Kamo A, Tominaga M, Kamata Y, Takamori K
  • Organizer: International Investigative Dermatology (IID) 2013
  • Place of Presentation: Edinburgh, Scotland
• [Presentation] A semaphorin story in atopic dermatitis (2013)
  • Author(s): Takamori K
  • Organizer: 7th World Congress on Itch
  • Place of Presentation: Boston, USA
  • Invited
• [Presentation] Histamine H4 receptor antagonists ineffective against itch and skin inflammation in atopic dermatitis mouse model (2013)
  • Author(s): Tominaga M, Kamo A, Osamu N, Tengara S, Kamata Y, Noguchi A, Takamori K
  • Organizer: 7th World Congress on Itch
  • Place of Presentation: Boston, USA
• [Presentation] Transcriptional regulation of human semaphorin 3A gene in normal epidermal keratinocytes: implication of application to intractable itch in atopic dermatitis (2013)
  • Author(s): Kamata Y, Tominaga M, Umehara Y, Kamo A, Takamori K
  • Organizer: 7th World Congress on Itch
  • Place of Presentation: Boston, USA
• [Presentation] Anti-pruritic effects of Neurotropin in NC/Nga mice with atopic dermatitis-like symptoms (2013)
  • Author(s): Kamo A, Tominaga M, Kamata Y, Nogchi A, Kimura U, Osamu N, Taneda K, Takamori K
  • Organizer: 7th World Congress on Itch
  • Place of Presentation: Boston, USA
• [Presentation] Eximer lamp induces directly cutaneous nerve degeneration in animal models for pruritus (2013)
  • Author(s): Kamo A, Tominaga M, Kamata Y, Takamori K
  • Organizer: 22nd Congress of the European Academy of Dermatology and Venereology (EADV)
  • Place of Presentation: Istanbul, Turkey
• [Presentation] かゆみのメカニズムと制御―保湿剤の有効性― (2013)
  • Author(s): 髙森建二
  • Organizer: 第112回日本皮膚科学会総会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 透析そう痒症の病態と治療
  • Author(s): 髙森建二
  • Organizer: 滋賀県皮膚科医会学術講演会
  • Place of Presentation: 草津
  • Invited
• [Presentation] 皮膚研究の最前線～皮膚のバリア機能の解明は皮膚所見の見方をどう変えたか～
  • Author(s): 髙森建二
  • Organizer: 日本透析学会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 透析そう痒い症はなぜ痒い
  • Author(s): 髙森建二
  • Organizer: 透析患者のかゆみを考える夕べ
  • Place of Presentation: 山形
  • Invited
• [Presentation] 透析のかゆみを科学する‐メカニズムと対策‐
  • Author(s): 髙森建二
  • Organizer: 練馬区皮膚科医会講演会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 小児アトピー性皮膚炎における積極的な治療介入の有用性
  • Author(s): 髙森建二
  • Organizer: 第37回日本小児皮膚科学会学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] かゆみの病態と治療の最近の話題―特にアトピー性皮膚炎のかゆみのメカニズムと対策について―
  • Author(s): 髙森建二
  • Organizer: 第63回関東耳鼻咽喉科アレルギー懇話会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 透析そう痒症はなぜ痒い―メカニズムと対策―
  • Author(s): 髙森建二
  • Organizer: 青森レミッチ講演会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 透析の伴いかゆみを制御する
  • Author(s): 髙森建二
  • Organizer: 富山透析そう痒症フォーラム
  • Place of Presentation: 富山
  • Invited
• [Presentation] 透析
  • Author(s): 髙森建二
  • Organizer: 第一回筑紫透析フォーラム
  • Place of Presentation: 福岡
  • Invited
• [Book] Itch-Management in Clinical Practice (2016)
  • Author(s): Kamata Y, Tominaga M, Takamori K.
  • Publisher: Medical and Scientific Publishers
• [Book] Pruritus Second Edition (2016)
  • Author(s): Tominaga M, Takamori K.
  • Publisher: Springer Science+Business Media
• [Book] 抗ヒスタミン薬．膠原病・リウマチ・アレルギー研修ノート (2016)
  • Author(s): 鎌田弥生、髙森建二.
  • Publisher: 診断と治療社
• [Book] Itch sensitization: NGF, semaphorins. Itch: Mechanisms and Treatment. (2014)
  • Author(s): Tominaga M, Takamori K
  • Total Pages: 441
  • Publisher: CRC Press, Taylor and Francis Group, LLC
• [Book] 皮膚科臨床アセット18 紅斑と痒疹 病態・治療の新たな展開 (2013)
  • Author(s): 髙森建二
  • Total Pages: 308
  • Publisher: 中山書店
• [Book] 抗ヒスタミン薬～達人の処方箋Ｒx～ (2013)
  • Author(s): 髙森建二
  • Total Pages: 302
  • Publisher: メディカルレビュー社
• [Remarks] 順天堂大学大学院医学研究科環境医学研究所 高森建二研究グループ
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/k4_takamori.html
• [Remarks] 順天堂大学大学院医学研究科環境医学研究所 高森建二グループ
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/k4_takamori.html
• [Remarks] 順天堂大学大学院医学研究科環境医学研究所高森建二グループホームページ
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/kankyo_igaku/k4_takamori.html
• [Patent(Industrial Property Rights)] セマフォリン3A遺伝子発現増強剤、及びセマフォリン3Aタンパク産生亢進剤 (2015)
  • Inventor(s): 吉岡康子、鎌田弥生、冨永光俊、高森建二
  • Industrial Property Rights Holder: 吉岡康子、鎌田弥生、冨永光俊、高森建二
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-074574
  • Filing Date: 2015-03-31
• [Patent(Industrial Property Rights)] 掻痒性皮膚疾患の治療又は予防 (2014)
  • Inventor(s): 梅原芳恵、鎌田弥生、冨永光俊、ニヨンサバ・フランソワ、高森建二
  • Industrial Property Rights Holder: 梅原芳恵、鎌田弥生、冨永光俊、ニヨンサバ・フランソワ、高森建二
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-177778
  • Filing Date: 2014-09-02
• [Patent(Industrial Property Rights)] セマフォリン3Aの発現調節法 (2013)
  • Inventor(s): 鎌田弥生、冨永光俊、高森建二
  • Industrial Property Rights Holder: 鎌田弥生、冨永光俊、高森建二
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-097100
  • Filing Date: 2013-05-02