| Project/Area Number |
25460730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kansai University of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Taniguchi Wataru 和歌山県立医科大学, 医学部, 助教 (20453194)
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| Co-Investigator(Renkei-kenkyūsha) |
Yamanaka Manabu 和歌山県立医科大学, 医学部, 学内助教 (30597084)
Sonekatsu Mayumi 和歌山県立医科大学, 医学部, 学内助教 (40725579)
Nishio Naoko 和歌山県立医科大学, 医学部, 特別研究員 (40648359)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 脊髄電気刺激 / パッチクランプ法 / in vivo パッチクランプ法 / 外向き電流 / SCS / slow IPSC / outward current / シグナル伝達 / ソマトスタチン / 抑制性シナプス電流 |
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| Outline of Final Research Achievements |
Spinal cord electrical stimulation（SCS）is a kind of the effective treatments for a chronic pain．However, mechanisms of SCS-evoked analgesia have been poorly understood. In this study, whole-cell patch-clamp recordings were performed from dorsal horn neurons in rat spinal cord slices to investigate SCS-induced effects. SCS produced slow inhibitory postsynaptic currents (IPSCs). This action was suggested that activation of GIRK channels induced slow IPSCs via somatostatin receptors. Moreover, we analyzed the stimulation condition to get the largest slow IPSCs by SCS, although this study has a limitation because it was animal experiment.
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