• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A mechanism of spinal cord electrical stimulation-induced analgesia related to somatostatin

Research Project

Project/Area Number 25460730
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pain science
Research InstitutionKansai University of Health Sciences

Principal Investigator

Nakatsuka Terumasa  関西医療大学, 保健医療学部, 客員教授 (30380752)

Co-Investigator(Kenkyū-buntansha) Taniguchi Wataru  和歌山県立医科大学, 医学部, 助教 (20453194)
Co-Investigator(Renkei-kenkyūsha) Yamanaka Manabu  和歌山県立医科大学, 医学部, 学内助教 (30597084)
Sonekatsu Mayumi  和歌山県立医科大学, 医学部, 学内助教 (40725579)
Nishio Naoko  和歌山県立医科大学, 医学部, 特別研究員 (40648359)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords脊髄電気刺激 / パッチクランプ法 / in vivo パッチクランプ法 / 外向き電流 / SCS / slow IPSC / outward current / シグナル伝達 / ソマトスタチン / 抑制性シナプス電流
Outline of Final Research Achievements

Spinal cord electrical stimulation(SCS)is a kind of the effective treatments for a chronic pain.However, mechanisms of SCS-evoked analgesia have been poorly understood. In this study, whole-cell patch-clamp recordings were performed from dorsal horn neurons in rat spinal cord slices to investigate SCS-induced effects. SCS produced slow inhibitory postsynaptic currents (IPSCs). This action was suggested that activation of GIRK channels induced slow IPSCs via somatostatin receptors. Moreover, we analyzed the stimulation condition to get the largest slow IPSCs by SCS, although this study has a limitation because it was animal experiment.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (29 results)

All 2016 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (16 results) (of which Int'l Joint Research: 3 results) Book (9 results)

  • [Journal Article] Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia-neuron interaction.2016

    • Author(s)
      Sonekatsu M, Taniguchi W, Yamanaka M, Nishio N, Tsutsui S, Yamada H, Yoshida M, Nakatsuka T.
    • Journal Title

      Molecular Pain

      Volume: 12 Pages: 1-12

    • DOI

      10.1177/1744806916644927

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TRPV1 channels induce Knee osteoarthritis pain: in vivo patch-clamp analysis2014

    • Author(s)
      Taniguchi W, Nishio N, Yamanaka M, Kiyoyuki Y, Sonekatsu M, Yoshida M, Nakatsuka T
    • Journal Title

      Pain Research

      Volume: 29 Pages: 171-179

    • NAID

      130004692192

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] A role of CGRP on excitatory synaptic transmission in spinal substantia gelatinosa neurons2014

    • Author(s)
      Nishio N, Taniguchi W, Miyake Y, Kiyoyuki Y, Yamanaka M, Sonekatsu M, Abe T, Takiguchi N, Yoshida M, Nakatsuka T
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: 35 Pages: 10-15

    • NAID

      40020382940

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reactive oxygen species enhance excitatory synaptic transmission in rat spinal dorsal horn neurons by activating TRPA1 and TRPV1 channels.2013

    • Author(s)
      Nishio N, Taniguchi W, Sugimura YK, Takiguchi N, Yamanaka M, Kiyoyuki Y, Yamada H, Miyazaki N, Yoshida M, Nakatsuka T
    • Journal Title

      Neuroscience

      Volume: 247 Pages: 201-12

    • DOI

      10.1016/j.neuroscience.2013.05.023

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] The role of NMDA receptor activation by IFNγ in the spinal dorsal horn neurons2016

    • Author(s)
      Sonekatsu M, Taniguchi W, Yamanaka M, Nishio N, Tsutsui S, Nishi H, Hashizume H, Yamada H, Yoshida M, Nakatsuka T.
    • Organizer
      Orthopedic Research Society 2016 Annual meeting
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2016-03-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In Vivo Patch-clamp Analysis Of Descending Facilitation Of Excitatory Transmission In The Spinal Dorsal Horn By The Anterior Cingulate Cortex Activation.2016

    • Author(s)
      Taniguchi W, Yamanaka M, Sonekatsu M, Nishio N, Tsutsui S, Nishi H, Hashizume H, Yamada H, Nakatsuka T, Yoshida M.
    • Organizer
      Orthopedic Research Society 2016 Annual meeting
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2016-03-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interferon-gamma activates NMDA receptors in the dorsal horn of spinal cord2015

    • Author(s)
      Sonekatsu M, Taniguchi W, Yamanaka M, Nishio N, Tsutsui S, Hashizume H, Yoshida M, Nakatsuka T.
    • Organizer
      Society for Neuroscience Annual meeting 2015
    • Place of Presentation
      Chicago
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo patch-clamp analysis of the pain mechanism by TRPA1 and TRPM8 activation on substantia gelatinosa neurons in the spinal cord2014

    • Author(s)
      Yamanaka M, Taniguchi W, Sonekatsu M, Nishio N, Abe T, Mine N, Miyazaki N, Nakatsuka T, Yoshida M
    • Organizer
      44th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington, D.C.
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 前帯状皮質から脊髄後角に至る経路は下行性疼痛賦活系を形成する2014

    • Author(s)
      谷口亘 山中学 曽根勝真弓 阿部唯一 峰巨 筒井俊二 橋爪洋 山田宏 中塚映政 吉田宗人
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-09 – 2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 情動中枢前帯状皮質の活性化は脊髄後角で直接痛みを増強する.2014

    • Author(s)
      谷口亘, 山中学, 西尾尚子, 曽根勝真弓, 阿部唯一, 峰巨, 筒井俊二, 橋爪洋, 山田宏, 中塚映政, 吉田宗人
    • Organizer
      第43回日本脊椎脊髄病学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-17 – 2014-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Activation of TRPV1 channels is involved in knee osteoarthritis pain -in vivo patch-clamp analysis-.2013

    • Author(s)
      Taniguchi W, Nishio N, Takiguchi N, Yamanaka M, Kiyoyuki Y, Sakurai Y, Abe T, Mine N, Miyazaki N, Yoshida M, Nakatsuka T
    • Organizer
      43rd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2013 Research-status Report
  • [Presentation] Patch-clamp analysis of anti-spasticity effect by baclofen in spinal ventral horn neurons.2013

    • Author(s)
      Abe T, Taniguchi W, Miyazaki N, Mine N, Takiguchi N, Yamanaka M, Yoshida M, Nakatsuka T
    • Organizer
      43rd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2013 Research-status Report
  • [Presentation] Leukotriene enhances NMDA induced inward currents of dorsal horn neurons in spinal cord of rats after peripheral nerve injury.2013

    • Author(s)
      Kiyoyuki Y, Yamanaka H, Kobayashi K, Taniguchi W, Nishio N, Okubo M, Nakatsuka T, Noguchi K
    • Organizer
      43rd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2013 Research-status Report
  • [Presentation] TRPV1チャネルを介した変形性膝関節症性疼痛-in vivo パッチクランプ法を用いた解析-2013

    • Author(s)
      谷口亘, 瀧口登, 山中学, 西尾尚子, 清行康邦, 櫻井悠加, 吉田宗人, 中塚映政
    • Organizer
      第35回日本疼痛学会
    • Place of Presentation
      大宮
    • Related Report
      2013 Research-status Report
  • [Presentation] TRPV1チャネルは変形性膝関節症性疼痛を増強する-in vivoパッチクランプ法を用いた解析-2013

    • Author(s)
      谷口亘, 瀧口登, 山中学, 西尾尚子, 峰巨, 阿部唯一, 宮崎展行, 吉田宗人, 中塚映政
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
  • [Presentation] 情動中枢の帯状回は脊髄後角に下行性疼痛賦活系を形成する2013

    • Author(s)
      谷口亘, 杉村弥恵, 山中学, 西尾尚子, 曽根勝真弓, 吉田宗人, 中塚映政
    • Organizer
      第6回日本運動器疼痛学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] TRPV1は変形性膝関節症を増強する-in vivoパッチクランプ法を用いた解析-2013

    • Author(s)
      谷口亘, 瀧口登, 山中学, 西尾尚子, 吉田宗人, 中塚映政
    • Organizer
      第11回整形外科痛みを語る会
    • Place of Presentation
      郡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 脊髄前角細胞に対するバクロフェンの抗痙縮メカニズム-patch‐clamp法による解析-2013

    • Author(s)
      阿部唯一, 中塚映政, 谷口亘, 瀧口登, 峰巨, 山中学, 宮崎展行, 吉田宗人
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉
    • Related Report
      2013 Research-status Report
  • [Presentation] ラット脊髄膠様質ニューロンの興奮性シナプス伝達に及ぼすCGRPの作用.

    • Author(s)
      西尾尚子, 谷口亘, 三宅悠介, 清行康邦, 山中学, 曽根勝真弓, 阿部唯一, 瀧口登, 吉田宗人, 中塚映政.
    • Organizer
      第35回脊髄機能診断研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 脊髄前角細胞におけるバクロフェンの抗痙縮メカニズム-patch‐clamp法による解析-.

    • Author(s)
      阿部唯一, 谷口亘, 峰巨, 山中学, 曽根勝真弓, 西尾尚子, 宮崎展行, 中塚映政, 吉田宗人.
    • Organizer
      第35回脊髄機能診断研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Book] 最新医学 71(2) 痛みのClinical Neuroscience 8 脊髄機能変化と痛み:アロディニアなどのメカニズムを巡って.2016

    • Author(s)
      谷口亘, 中塚映政
    • Total Pages
      4
    • Publisher
      最新医学社
    • Related Report
      2015 Annual Research Report
  • [Book] JOHNS 32(5) 特集“痛みとかゆみ” 【痛み・かゆみの科学】 3.痛みの神経伝達機序2016

    • Author(s)
      谷口亘, 中塚映政
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2015 Annual Research Report
  • [Book] 基礎編A.基礎知識12.痛みの研究手法-パッチクランプ法 痛みのScience &Practice シリーズ6「痛み診療キーポイント」2014

    • Author(s)
      谷口亘, 中塚映政.
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 基礎編C.脊髄 1.脊髄後角 痛みのScience &Practice シリーズ6「痛み診療キーポイント」2014

    • Author(s)
      谷口亘, 中塚映政.
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 基礎編D.脳 2.神経可塑性 痛みのScience &Practice シリーズ6「痛み診療キーポイント」2014

    • Author(s)
      谷口亘, 中塚映政.
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 基礎編D.脳 3.中枢性感作 痛みのScience &Practice シリーズ6「痛み診療キーポイント」2014

    • Author(s)
      谷口亘, 中塚映政.
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] Neuroprotection and Regeneration of the Spinal Cord. Chaptor31. Spinal synaptic plasticity in chronic pain.2014

    • Author(s)
      Wataru Taniguchi, Terumasa Nakatsuka
    • Total Pages
      12
    • Publisher
      Springer Japan
    • Related Report
      2013 Research-status Report
  • [Book] 先端医療シリーズ44 臨床医のための最新整形外科 第2章痛みのメカニズムと最新治療 1. 痛みのメカニズム2013

    • Author(s)
      谷口亘, 中塚映政
    • Total Pages
      4
    • Publisher
      先端医療技術研究所
    • Related Report
      2013 Research-status Report
  • [Book] 痛みのScience &Practice シリーズ2「痛みの薬物治療」 1章総論 5.炎症痛のメカニズム2013

    • Author(s)
      谷口亘, 中塚映政
    • Total Pages
      9
    • Publisher
      文光堂
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi