A mechanism of spinal cord electrical stimulation-induced analgesia related to somatostatin
| Project/Area Number |
25460730
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Kansai University of Health Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Taniguchi Wataru 和歌山県立医科大学, 医学部, 助教 (20453194)
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| Co-Investigator(Renkei-kenkyūsha) |
Yamanaka Manabu 和歌山県立医科大学, 医学部, 学内助教 (30597084)
Sonekatsu Mayumi 和歌山県立医科大学, 医学部, 学内助教 (40725579)
Nishio Naoko 和歌山県立医科大学, 医学部, 特別研究員 (40648359)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 脊髄電気刺激 / パッチクランプ法 / in vivo パッチクランプ法 / 外向き電流 / SCS / slow IPSC / outward current / シグナル伝達 / ソマトスタチン / 抑制性シナプス電流 |
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| Outline of Final Research Achievements |
Spinal cord electrical stimulation（SCS）is a kind of the effective treatments for a chronic pain．However, mechanisms of SCS-evoked analgesia have been poorly understood. In this study, whole-cell patch-clamp recordings were performed from dorsal horn neurons in rat spinal cord slices to investigate SCS-induced effects. SCS produced slow inhibitory postsynaptic currents (IPSCs). This action was suggested that activation of GIRK channels induced slow IPSCs via somatostatin receptors. Moreover, we analyzed the stimulation condition to get the largest slow IPSCs by SCS, although this study has a limitation because it was animal experiment.
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Report
(4 results)
Research Products
(29 results)
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[Presentation] The role of NMDA receptor activation by IFNγ in the spinal dorsal horn neurons2016
Author(s)
Sonekatsu M, Taniguchi W, Yamanaka M, Nishio N, Tsutsui S, Nishi H, Hashizume H, Yamada H, Yoshida M, Nakatsuka T.
Organizer
Orthopedic Research Society 2016 Annual meeting
Place of Presentation
Orlando, Florida
Year and Date
2016-03-01
Related Report
Int'l Joint Research
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[Presentation] In Vivo Patch-clamp Analysis Of Descending Facilitation Of Excitatory Transmission In The Spinal Dorsal Horn By The Anterior Cingulate Cortex Activation.2016
Author(s)
Taniguchi W, Yamanaka M, Sonekatsu M, Nishio N, Tsutsui S, Nishi H, Hashizume H, Yamada H, Nakatsuka T, Yoshida M.
Organizer
Orthopedic Research Society 2016 Annual meeting
Place of Presentation
Orlando, Florida
Year and Date
2016-03-01
Related Report
Int'l Joint Research
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[Presentation] 情動中枢前帯状皮質の活性化は脊髄後角で直接痛みを増強する.2014
Author(s)
谷口亘, 山中学, 西尾尚子, 曽根勝真弓, 阿部唯一, 峰巨, 筒井俊二, 橋爪洋, 山田宏, 中塚映政, 吉田宗人
Organizer
第43回日本脊椎脊髄病学会学術集会
Place of Presentation
京都
Year and Date
2014-04-17 – 2014-04-19
Related Report
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[Presentation] Activation of TRPV1 channels is involved in knee osteoarthritis pain -in vivo patch-clamp analysis-.2013
Author(s)
Taniguchi W, Nishio N, Takiguchi N, Yamanaka M, Kiyoyuki Y, Sakurai Y, Abe T, Mine N, Miyazaki N, Yoshida M, Nakatsuka T
Organizer
43rd Annual Meeting of Society for Neuroscience
Place of Presentation
San Diego
Related Report
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