| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
The objective of this study is to investigate the clinical significance of measurement of urinary albumin excretion by the novel HPLC method for predicting faster decline of glomerular filtration, and future development of cardiovascular disease and microalbuminuria in general population with normoalbuminuria. Using our cohort established in annual health examination at Kita-akita city in 2011, 565 subjects with noromoalbuminuria at baseline have been successfully followed up for five years. High urinary albumin levels of both conventional and HPLC methods at baseline predicted future development of microalbuminuria and faster decline of estimated glomerular filtration rate during 5-year-observation. The low degrees of difference in urinary albumin levels between conventional and HPLC methods, which may suggest disturbance of tubular handling of albumin, also did. The evaluation of factors related to development of cardiovascular diseases is ongoing at now.
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