Searching genes susceptible for life-style related diseases in consideration with gene-environmental interaction.
Project/Area Number |
25460737
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Hirosaki University |
Principal Investigator |
Daimon Makoto 弘前大学, 医学(系)研究科(研究院), 教授 (20241698)
|
Co-Investigator(Kenkyū-buntansha) |
OIZUMI TOSHIHIDE 山形大学, 大学院医学研究科, 助教 (00344797)
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Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 分子疫学 / 分疫学研究 / 高畠研究 / 糖尿病 / 脂質異常症 / コホート研究 / 死亡 / 分子疫学研究 / 全死亡 / 高血圧 / 住民研究 / 癌死亡 |
Outline of Final Research Achievements |
Most studies to find genes susceptible for life-style related diseases have been conducted without regarding life-style factors per se. This strategy conveys a risk that the results obtained were not useful in ordinary clinical settings. Therefore, we examined gene-environmental interactions for several genetic factors known as susceptible for such life-style rerated diseases, and tried to invent methods to use such data of interactions to evaluate risks of the diseases. We further extended the knowledge of classical risk factor for life-style rerated diseases, together with clarifying several environmental factors such as plasma renin activity, aldosterone concentration, their ratio as a risk for death and/or life-style related disease. These findings seem to be very useful in ordinary clinical settings and thus pave the way to the precision medicine.
|
Report
(4 results)
Research Products
(17 results)
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[Journal Article] Gene-environment interactions in obesity: implication for future applications in preventive medicine.2016
Author(s)
Nakamura S, Narimatsu H, Sato H, Sho R, Otani K, Kawasaki R, Karasawa S, Daimon M, Yamashita H, Kubota I, Ueno Y, Kato T, Yoshioka T, Fukao A, Kayama T.
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Journal Title
J Hum Genet.
Volume: 61
Issue: 4
Pages: 317-322
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Lower aldosterone-renin ratio is a risk factor for total and cancer death in Japanese individuals: the Takahata study.2015
Author(s)
Daimon M, Konta T, Oizumi T, Kameda W, Susa S, Terui K, Nigawara T, Kageyama K, Ueno Y, Kubota I, Yamashita H, Kayama T, Kato T.
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Journal Title
Clin Endocrinol (Oxf)
Volume: 82
Issue: 4
Pages: 489-496
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study.2014
Author(s)
Otaki Y, Watanabe T, Takahashi H, Hirayama A, Narumi T, Kadowaki S, Honda Y, Arimoto T, Shishido T, Miyamoto T, Konta T, Shibata Y, Fukao A, Daimon M, Ueno Y, Kato T, Kayama T, Kubota I.
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Journal Title
PLoS One
Volume: 9
Issue: 5
Pages: e94834-e94834
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Likelihood ratio-based integrated personal risk assessment of type 2 diabetes2014
Author(s)
Sato N, Htun NC, Daimon M, Tamiya G, Kato T, Kubota I, Ueno Y, Yamashita H, Fukao A, Kayama T, Muramatsu M.
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Journal Title
Endocrine Journal
Volume: 61
Issue: 10
Pages: 967-988
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access
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[Journal Article] Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes.2014
Author(s)
Pereira TV, Kimura L, Suwazono Y, Nakagawa H, Daimon M, Oizumi T, Kayama T, Kato T, Li L, Chen S, Gu D, Renner W, Marz W, Yamada Y, Bagos PG, Mingroni-Netto RC.
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Journal Title
Mol Biol Rep
Volume: in press
Issue: 5
Pages: 3113-3125
DOI
Related Report
Peer Reviewed
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[Presentation] 脂質異常症治療は死亡率改善と関連する2015
Author(s)
大門 眞, 大泉 俊英, 亀田 亘, 諏佐 真治, 松井 淳, 村上 宏, 上野 義之, 久保田 功, 山下 英俊, 嘉山 孝正, 加藤 丈夫
Organizer
第88回日本内分泌学会学術総会
Place of Presentation
ホテルニューオータニ東京( 東京都千代田区紀尾井町 )
Year and Date
2015-04-24
Related Report
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[Presentation] 血中アデイポネクチン値と心血管疾患発症との関連。2014
Author(s)
多田 杏子, 海野 航, 柄澤 繁, 和田 輝里子,亀田 亘, 諏佐 真治, 渡邉健太郎、大泉 俊英, 大門 眞, 加藤 丈夫。
Organizer
第57回日本糖尿病学会年次学術集会。
Place of Presentation
大阪
Year and Date
2014-05-22 – 2014-05-24
Related Report
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[Presentation] FTO genetic variants, dietary intake, and body mass index: results from 177,330 individuals.2013
Author(s)
Qi Q, Kilpelainen T, Downer M, Tanaka T, Smith C, Sorense T, Hu F, Loos R, Nettleton J, Qi L, FTO Gene and Dietary Intake Consortium (Daimon M, et al).
Organizer
American Society of Human Genetics 3013 Meeting
Place of Presentation
Boston, USA
Related Report